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31Phosphorus NMR Studies of Mercuric Chloride Nephrotoxicity in the in Vitro Perfused Rat Kidney

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Nephrotoxicity

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Abstract

31P Nuclear Magnetic Resonance (NMR) studies of the effect of hypoxia on ATP levels in the isolated perfused rat kidney have shown that a step-wise decrease in oxygen delivery is associated with a step-wise decrease in ATP to a new plateau level (1). The decrement in ATP was closely correlated with the volume extent of cellular necrosis determined from morphometric analysis of the same kidneys at the end of the perfusion period.

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References

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Authors and Affiliations

  1. Nuffield Department of clinical Medicine and Department of Biochemistry, University of Oxford, Oxford, UK

    Z. H. Endre, P. J. Ratcliffe, L. G. Nicholls, J. G. G. Ledingham, J. D. Tange & G. K. Radda

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  1. Z. H. Endre
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  2. P. J. Ratcliffe
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  3. L. G. Nicholls
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  4. J. G. G. Ledingham
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  5. J. D. Tange
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  6. G. K. Radda
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Editor information

Editors and Affiliations

  1. The Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey, UK

    P. H. Bach

  2. ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK

    E. A. Lock

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© 1989 Springer Science+Business Media New York

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Endre, Z.H., Ratcliffe, P.J., Nicholls, L.G., Ledingham, J.G.G., Tange, J.D., Radda, G.K. (1989). 31Phosphorus NMR Studies of Mercuric Chloride Nephrotoxicity in the in Vitro Perfused Rat Kidney. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_78

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  • DOI: https://doi.org/10.1007/978-1-4757-2040-2_78

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2042-6

  • Online ISBN: 978-1-4757-2040-2

  • eBook Packages: Springer Book Archive

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