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The Devil is in the Dose: Complexity of Receptor Systems and Responses

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Hormesis

Abstract

Through evolutionary history the primary mechanism by which the cells or tissues of most organisms sense their environment has been the heptahelical G protein–coupled receptor (GPCR). This prototypic receptive entity has its origins in the earliest forms of life and often comprises up to 5% of the genome of most unicellular and multicellular life forms. The GPCR system has adapted to perceive almost all forms of environmental entities, for example, photons, odorants, lipids, carbohydrates, peptides, and nucleic acids. The GPCR system has also likely adapted to the presence of exogenous compounds that may at some doses be deleterious but at lower levels may indeed possess beneficial actions. Therefore, with respect to the evolutionary pressure of diverse environments, it would be an extreme advantage for an organism to adapt multiple components of its primary receptive system to take advantage of any beneficial effects of agents present in harsh or damaging environments.

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Author information

Authors and Affiliations

  1. Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 21224, Baltimore, MD, USA

    Wayne Chadwick & Stuart Maudsley

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  1. Wayne Chadwick
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  2. Stuart Maudsley
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Correspondence to Stuart Maudsley .

Editor information

Editors and Affiliations

  1. Lab. Neurosciences, National Institute on Aging, Nathan Shock Drive 5600, Baltimore, 21224, U.S.A.

    Mark P. Mattson

  2. Dept. Environmental Health Sciences, University of Massachusetts, Morrill Science Center N344, Amherst, 01003-5712, U.S.A.

    Edward J. Calabrese

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Chadwick, W., Maudsley, S. (2010). The Devil is in the Dose: Complexity of Receptor Systems and Responses. In: Mattson, M., Calabrese, E. (eds) Hormesis. Humana Press. https://doi.org/10.1007/978-1-60761-495-1_5

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