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Molecular Characterization of Salivary Gland Carcinomas

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Salivary Gland Cancer

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Abstract

The recently updated WHO classification of head and neck tumors has listed more than 20 (sub-)types of salivary gland cancers. Although there was a consensus of the Board that diagnosis on histological criteria alone may be inaccurate, the editors finally reasoned that the necessary setup for molecular analyses is not globally available, as yet, or the data are either not convincing or robust enough to supplement the histological and immunohistochemical diagnostic tools. Nevertheless, the increasing knowledge about tumor-type-specific translocations, point mutations, and amplifications in salivary gland cancers needs more explanatory comments than the new WHO fascicle could afford, particularly taking into account the already established molecular support of diagnostic and predictive pathology in specialized clinical centers. In the German Salivary Gland Expert Network (www.hansepathnet.de), we advocate the application of molecular analyses for clinicopathological purposes in mucoepidermoid, adenoid cystic, and secretory carcinomas, while more translational research is necessary before molecular tools can be applied in other neoplasias covered in this chapter, in routine clinical practice.

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Abbreviations

a.k.a.:

Also known as

ACC:

Acinic cell carcinoma

AdCC:

Adenoid cystic carcinoma

AR:

Androgen receptor

CAMSG:

Cribriform adenocarcinoma of minor salivary glands

CREB:

cAMP response element-binding protein

CXPA:

Carcinoma ex pleomorphic adenoma

FGF-IGF-PI3K:

Fibroblast growth factor-insulin-like growth factor-phosphatidylinositol 3-kinase pathway

FISH:

Fluorescence in situ hybridization

HCCC:

Hyalinizing clear-cell carcinoma

IDC:

Low-grade intraductal carcinoma

MAPK:

Mitogen-activated protein kinase

MASC:

Mammary analogue secretory carcinoma

MEC:

Mucoepidermoid carcinoma

NOS:

Not otherwise specified

PA:

Pleomorphic adenoma

PAC:

Polymorphous adenocarcinoma

PI3K:

Phosphatidylinositol 3-kinase

RT-PCR:

Reverse transcription polymerase chain reaction

SC:

Secretory breast carcinoma

SDC:

Salivary duct carcinoma

SGC:

Salivary gland carcinomas

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Authors and Affiliations

  1. Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden

    André Fehr

  2. Institut für Medizinische Genetik, Universitätsmedizin Rostock, Rostock, Germany

    Jörn Bullerdiek

  3. Pathologie Bremen, Bremen, Germany

    Thorsten Jaekel

  4. Gerhard-Seifert-Referenzzentrum, Hamburg, Germany

    Thomas Löning

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  1. André Fehr
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  2. Jörn Bullerdiek
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  3. Thorsten Jaekel
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  4. Thomas Löning
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Correspondence to André Fehr .

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Editors and Affiliations

  1. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Milan, Italy

    Lisa Licitra

  2. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Milan, Italy

    Laura D. Locati

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Fehr, A., Bullerdiek, J., Jaekel, T., Löning, T. (2019). Molecular Characterization of Salivary Gland Carcinomas. In: Licitra, L., Locati, L. (eds) Salivary Gland Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-02958-6_2

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  • DOI: https://doi.org/10.1007/978-3-030-02958-6_2

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