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Translational Challenges: Lymph Node Tissue Engineering

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Regenerative Medicine and Plastic Surgery

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Abstract

Chronic lymphedema is a progressive pathological condition of the lymphatic system often leading to a clinical picture of disfigurement and decreased mobility and function. The authors discuss clinical presentation with diagnosis and stages and traditional treatment.

Typically, a clinical history and physical examination are sufficient to provide a clear diagnosis of chronic lymphedema, but in obscure cases lymphoscintigraphy and/or magnetic resonance imaging will lead to a diagnosis. Most innovative regenerative medicine paradigms are related to cell processing and culturing, but combined autologous lymph node fragments and biodegradable scaffolds are particularly promising.

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Authors and Affiliations

  1. Department for Plastic and Hand Surgery, Klinkum rechts der Isar, Technical University of Munich, Munich, Germany

    Philipp Neßbach

  2. Department of Plastic and Hand Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

    Matthias M. Aitzetmüller

  3. Section of Plastic and Reconstructive Surgery, Department of Trauma, Hand and Reconstructive Surgery, Westfaelische Wilhelms, University of Muenster, Muenster, Germany

    Matthias M. Aitzetmüller

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  1. Philipp Neßbach
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  2. Matthias M. Aitzetmüller
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Correspondence to Philipp Neßbach .

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Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Neßbach, P., Aitzetmüller, M.M. (2019). Translational Challenges: Lymph Node Tissue Engineering. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19958-6_25

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