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Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence

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Reviews on New Drug Targets in Age-Related Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1286))

Abstract

Aging is a biological process with effects at the molecular, cellular, tissue, organ, system, and organismal levels and is characterized by decline in physical function and higher risks of age-related diseases. The use of anti-aging drugs for disease prevention has become a high priority for science and is a new biomedicine trend. Geroprotectors are compounds which slow aging and increase lifespan of the organism in question. The common painkiller aspirin, a member of the non-steroidal anti-inflammatory drug (NSAID) family, is one of the potential geroprotective agents. Aspirin is often used in treatment of mild to moderate pain. It has anti-inflammatory and anti-pyretic properties and acts as an inhibitor of cyclooxygenase which results in inhibition of prostaglandin. Acetylsalicylic acid as an active compound of aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. Aspirin has shown life-extending effects in numerous model organisms. This chapter reviews the evidence for clinical efficacy of aspirin including cardiovascular disease prevention, anti-cancer effects, and improvement of cognitive function. However, there are some limitations of these therapies, including the risk of excessive bleeding. We have also summarized numerous experimental and analytical data that support health and longevity benefits of aspirin treatment by affecting pro-longevity pathways.

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Acknowledgments

This work was partially supported by the Ministry of Education and Science of Ukraine (no. 0117U006426), National Research Foundation of Ukraine (no. 2020.02/0118) and a Discovery grant from the Natural Sciences and Engineering Research Council of Canada (no. 6793).

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Authors and Affiliations

  1. Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine

    Oleh Lushchak, Olha Strilbytska & Nadya Stefanyshyn

  2. Clinic for Heart Surgery, University clinic of Martin Luther University, Halle, Germany

    Veronika Piskovatska

  3. Medical University, Ivano-Frankivsk, Ukraine

    Iryna Kindrat

  4. Laboratory of Epigenetics, D.F. Chebotarev Institute of Gerontology, NAMS, Kyiv, Ukraine

    Alexander Koliada & Alexander Vaiserman

  5. Laboratory of Experimental Toxicology and Mutagenesis L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, MHU, Kyiv, Ukraine

    Volodymyr Bubalo

  6. Department of Biology, Carleton University, Ottawa, Canada

    Kenneth B. Storey

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  1. Oleh Lushchak
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Correspondence to Oleh Lushchak .

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  1. Laboratory of Neuroproteomics Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas (UNICAMP), Sao Paulo, Brazil

    Paul C. Guest

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Lushchak, O. et al. (2021). Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence. In: Guest, P.C. (eds) Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1286. Springer, Cham. https://doi.org/10.1007/978-3-030-55035-6_11

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