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Therapeutic Strategies and Nano-Drug Delivery Applications in Management of Aging Alzheimer’s Disease

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Reviews on New Drug Targets in Age-Related Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1286))

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline. Existing drugs only suppress symptoms or delay further deterioration but do not address the cause of the disease. In spite of screening numerous drug candidates against various molecular targets of AD, only a few candidates, such as acetylcholinesterase inhibitors, are currently utilized as an effective clinical therapy. Currently, nano-based therapies can make a difference, providing new therapeutic options by helping drugs to cross the blood-brain barrier and enter the brain more effectively. The main aim of this review was to highlight advances in research on the development of nano-based therapeutics for improved treatment of AD.

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Funding

This research was supported by a National Research Foundation of Korea (NRF) grant, awarded by the Korean government (Ministry of Education, Science and Technology, no. NRF-2019R1G1A109740012).

Conflict of Interest The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Faculty of Pharmacy, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City, Vietnam

    Thuy Trang Nguyen

  2. Vietnam Sports Hospital, Ministry of Culture, Sports and Tourism, Hanoi, Vietnam

    Tuong Kha Vo

  3. Department of Industrial and Environmental Engineering, Gachon University, Seongnam-si, South Korea

    Giau Van Vo

  4. Department of Bionano Technology, Gachon University, Seongnam-si, South Korea

    Giau Van Vo

  5. School of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam

    Giau Van Vo

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  1. Thuy Trang Nguyen
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  2. Tuong Kha Vo
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  3. Giau Van Vo
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Editor information

Editors and Affiliations

  1. Laboratory of Neuroproteomics Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas (UNICAMP), Sao Paulo, Brazil

    Paul C. Guest

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Nguyen, T.T., Vo, T.K., Vo, G.V. (2021). Therapeutic Strategies and Nano-Drug Delivery Applications in Management of Aging Alzheimer’s Disease. In: Guest, P.C. (eds) Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1286. Springer, Cham. https://doi.org/10.1007/978-3-030-55035-6_13

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