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Syndecan-3: A Signaling Conductor in the Musculoskeletal System

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Proteoglycans in Stem Cells

Part of the book series: Biology of Extracellular Matrix ((BEM,volume 9))

Abstract

Syndecan-3 is a transmembrane proteoglycan, the largest of the four syndecan family members and the most mysterious. To date, the number of published studies involving syndecan-3 is only a small fraction of the number of studies involving the other subfamily member syndecan-1, yet, these few studies on syndecan-3 cover a whole range of biological functions and phenotypes suggesting that syndecan-3 might be the most eclectic and intereting of the four syndecans. In this review, we focus on what is currently known about the role of syndecan-3 in the musculoskeletal system, from development to aging, including regeneration and disease. We also briefly refer to known syndecan-3 functions in other tissues and systems in an attempt to summarize the most up-to-date knowledge while also instilling curiosity about this extraordinary biomolecule and, hopefully, inspiring more research into its biochemistry and biological functions.

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Authors and Affiliations

  1. Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA

    F. K. Jones & A. Pisconti

  2. School of Medicine, Keele University at the RJAH Orthopaedic Hospital, Keele, UK

    O. Kehoe

  3. Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

    A. Daroszewska & R. J. van’t Hof

  4. Department of Biochemistry and Metabolic Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK

    A. Daroszewska

  5. Department of Rheumatology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK

    A. Daroszewska

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  1. F. K. Jones
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  2. O. Kehoe
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  3. A. Daroszewska
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  4. R. J. van’t Hof
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  5. A. Pisconti
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Correspondence to A. Pisconti .

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  1. Department of Gynecology and Obstetrics, Muenster University, MĂĽnster, Germany

    Martin Götte

  2. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

    Karin Forsberg-Nilsson

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Jones, F.K., Kehoe, O., Daroszewska, A., van’t Hof, R.J., Pisconti, A. (2021). Syndecan-3: A Signaling Conductor in the Musculoskeletal System. In: Götte, M., Forsberg-Nilsson, K. (eds) Proteoglycans in Stem Cells. Biology of Extracellular Matrix, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-030-73453-4_7

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