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Description and Interpretation of Results; The Pathology Report

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Precision Cancer Medicine

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Abstract

The Final Report is where the expert pathologist has unique and critical influence upon the entire biomarker dependent therapeutic process, integrating all components as described in Part III.

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References

  • Aisenberg AC. Comment on lymphoma classification. New Engl J Med. 1977;297:206.

    Article  Google Scholar 

  • Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive fctors in breast cancer by IHC analysis. Mod Pathol. 1998;11:115–24.

    Google Scholar 

  • Bruni D, Angell HK, Galon J. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020. https://doi.org/10.1038/s41568-020-0285-7

  • Daltoé RD, Madeira KP, de Carvalho AA, de Rezende LCD, Silva IV, Rangel LBA. Evaluation of the progesterone receptor status in breast cancer using three different antibodies: a comparison by Allred score system. Int J Clin Exp Pathol. 2013;15:331–9. [Medline]

    Google Scholar 

  • De Winne K, Sorber L, Lambin S, et al. Immunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial. Virchows Arch. 2020. https://doi.org/10.1007/s00428-020-02921-6

  • Fassler DJ, Abousamra S, Gupta R, et al. Deep learning-based image analysis methods for brightfield-acquired multiplex immunohistochemistry images. Diagn Pathol. 2020;15:100. https://doi.org/10.1186/s13000-020-01003-0. https://www.leicabiosystems.com/resources/4-tips-for-digital-pathology-slide-scanning/

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fedchenko N, Reifenrath J. Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue—a review. Diagn Pathol. 2014;9:221. https://doi.org/10.1186/s13000-014-0221-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feng Z, Puri S, Moudgil T, wood W, Hoyt CC, Wang C, Urba BD, Bifulico CB, Fox BA. Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma. J Immunother Cancer. 2015;3:47. https://doi.org/10.1186/s40425-015-0091-z.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fitzgibbons PL, Dillon DA, Alsabeh R, Berman MA, Hayes DF, Hicks DG, Hughes KS, Nofech-Mozes S. Template for reporting results of biomarker testing of specimens from patients with carcinoma of the breast. Arch Pathol Lab Med. 2014;138:595–601. [Medline]

    Article  PubMed  Google Scholar 

  • Fridman WH, Pagès F, Sautès-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012;12:298–306. https://doi.org/10.1038/nrc3245.

    Article  CAS  PubMed  Google Scholar 

  • Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313(5795):1960–4. https://doi.org/10.1126/science.1129139.

    Article  CAS  PubMed  Google Scholar 

  • Hammond ME, Hayes DF, Dowsett M, et al. American Society of Clinical Oncology; College of American Pathologists. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab. 2010;134(7):e48–72. [Medline]

    Article  CAS  Google Scholar 

  • Hewitt SM, Robinowitz M, Bogen SA, Gown AM, Kalra KL, Otis CN, Spaulding B, Taylor CR. Quality assurance for design control and implementation of immunohistochemistry assays: approved guidelines, vol. 31. 2nd ed. Wayne, PA: Clinical Lab Standards Institute; 2011. p. 4.

    Google Scholar 

  • Hirsch FR, Varella-Garcia M, Bunn PA Jr, Di Maria MV, Veve R, Bremmes RM, Baron AE, Zeng C. Franklin w (2003) epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol. 2003;21:3798–807.

    Article  CAS  PubMed  Google Scholar 

  • Ilić IR, Stojanović NM, Radulović NS, Zivkovic VV, Randelovic PJ, Petrovic AS, Bozic M, Ilic RS. The quantitative ER immunohistochemical analysis in breast cancer: detecting the 3 + 0, 4 + 0, and 5 + 0 allred score cases. Medicina (Kaunas). 2019;55(8):461. https://doi.org/10.3390/medicina55080461.

    Article  Google Scholar 

  • Immunoscore. n.d. Accessed October 2020. http://www.immunoscore.org/history.shtml

  • Jasani B, Bänfer G, Fish R, Waelput W, Sucaet Y, Barker C, Whiteley JL, Walker J, Hovelinck R, Diezko R. Evaluation of an online training tool for scoring programmed cell death ligand-1 (PD-L1) diagnostic tests for lung cancer. Diagn Pathol. 2020;15(1):37. https://doi.org/10.1186/s13000-020-00953-9. PMID: 32303234; PMCID: PMC7164334.

  • Jensen TW, Ray T, Wang J, Li X, Naritoku WY, Han B, Bellafiore F, Bagaria SP, Cui X, Taylor CR, Ray PS. Diagnostic and prognostic value of FOXC1 expression in basal-like breast cancer: an omics-derived subtype-specific biomarker. JNCI. 2015;107(8):djv148. https://doi.org/10.1093/jnci/djv148.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Phillips T, Millett MM, Zhang X, Jansson M, Cleveland R, Simmons P, Cherryholmes G, Carnahan J, William J, Spaulding B, Satnick IR, Inzuna HD, Taylor CR, Cogswell J, Novotny J, Oroudjev E, Winther H. Development of a diagnostic programmed cell death 1-ligand 1 immunohistochemistry assay for Nivolumab therapy in melanoma. Appl Immunohistochem Mol Morph. 2018;26:6–12.

    Article  CAS  Google Scholar 

  • Phillips T, Simmons P, Inzunza HD, Cogswell J, Novotny J, Taylor CR, Zhang X. Development of an automated PD-L1 immunohistochemistry (IHC) assay for non small cell lung cancer. Appl Immunohistochem Mol Morph. 2015;23:541–9. https://doi.org/10.1097/PAI.0000000000000256.

    Article  CAS  Google Scholar 

  • Powsner SM, Costa J, Homer RJ. Clinicians are from mars and pathologists are from venus. Clinician interpretation of pathology reports. Arch Pathol Lab Med. 2000;124:1040–6.

    Article  CAS  PubMed  Google Scholar 

  • Pu T, Shui R, Shi J, Liang Z, Yang W, Bu H, Li Q, Zhang Z. External quality assessment (EQA) program for the immunohistochemical detection of ER, PR and Ki-67 in breast cancer: results of an interlaboratory reproducibility ring study in China. BMC Cancer. 2019;19:978. https://doi.org/10.1186/s12885-019-6210-3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rivenson Y, Wang H, Wei Z, et al. Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning. Nat Biomed Eng. 2019; https://doi.org/10.1038/s41551-019-0362-y. https://bioengineeringcommunity.nature.com/posts/44757-deep-learning-based-virtual-histology-staining-using-autofluorescence-of-label-free-tissue

  • Tan WCC, Nerurkar SN, Cai HY, Ng HHM, Wu D, Wee YTF, Lim JCT, Yeong J, Lim TKH. Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy. Cancer Commun (Lond). 2020;40(4):135–53. https://doi.org/10.1002/cac2.12023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170662/

    Article  Google Scholar 

  • Taylor CR. Predictive biomarkers and companion diagnostics. The future of immunohistochemistry—‘in situ proteomics’, or just a ‘stain’? Appl Immunohistochem Mol Morph. 2014;22:555–61.

    Article  Google Scholar 

  • Taylor CR. Milestones in immunohistochemistry and molecular morphology. Appl Immunohistochem Mol Morph. 2020;28:83–94.

    Article  Google Scholar 

  • Taylor CR, Cote RJ, editors. Immunomicroscopy: a diagnostic tool for the surgical pathologist. 3rd ed. Saunders, PA: Elsevier; 2005. (1st edition, Taylor was 1986; 2nd edition, Taylor and Cote was 1994)

    Google Scholar 

  • Taylor CR, Jadhav AP, Gholap A, Kamble G, Huang J, Gown A, Rimm DL, Doshi I. A multi-institutional study to evaluate automated whole slide scoring of immunohistochemistry for assessment of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer. Appl Immunohistochem Mol Morphol. 2019;27(4):263–9. https://doi.org/10.1097/PAI.0000000000000737.

    Article  CAS  PubMed  Google Scholar 

  • Umemura S, Osamura RY, Akiyama F, Honma K, Kurosumi M, Sasano H, Toyoshima S, Tsuda H, Ruschoff J, Sakamoto G. What causes discrepancies in HER2 testing for breast cancer? A Japanese ring study in conjunction with the global standard. Am J Clin Pathol. 2008;130:883–91. https://doi.org/10.1309/AJCP5UUMFMA5ZKII.

    Article  PubMed  Google Scholar 

  • Willis RA. Pathology of tumours. London: Butterworths; 1948.

    Google Scholar 

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Authors and Affiliations

  1. Discovery Life sciences Global Biomarker Services, Kassel, Hessen, Germany

    Bharat Jasani

  2. Institute of Pathology and Molecular Diagnostics & Institute for Digital Medicine, University Hospital Augsburg, Augsburg, Bavaria, Germany

    Ralf Huss

  3. Department of Pathology, University of Southern California, Los Angeles, CA, USA

    Clive R. Taylor

Authors
  1. Bharat Jasani
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  2. Ralf Huss
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  3. Clive R. Taylor
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Jasani, B., Huss, R., Taylor, C.R. (2021). Description and Interpretation of Results; The Pathology Report. In: Precision Cancer Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-84087-7_13

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  • DOI: https://doi.org/10.1007/978-3-030-84087-7_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-84086-0

  • Online ISBN: 978-3-030-84087-7

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