Abstract
The diagnosis of suspicious for high-grade urothelial carcinoma (SHGUC) is meant to reflect the presence of a small number of urothelial cells with increased nuclear-to-cytoplasmic ratio and severe nuclear atypia that falls short for a diagnosis of HGUC, but beyond atypia that is associated with the category of atypical urothelial cells (AUC). This chapter describes the detailed quantitative and qualitative cytomorphologic criteria needed for a diagnosis of SHGUC. It also discusses the prevalence of this diagnosis in the literature and the associated risk of high-grade malignancy (ROHM).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Stanzione N, Ahmed T, Fung PC, Cai D, Lu DY, Sumida LC, Moatamed NA. The continual impact of the Paris system on urine cytology, a 3-year experience. Cytopathology. 2020;31(1):35–40. PMID: 31596979.
de Paula R, Oliveira A, Nunes W, Bovolim G, Domingos T, De Brot L, Bezerra S, Cunha I, Morini M, Saieg M. Two-year study on the application of the Paris system for urinary cytology in a cancer centre. Cytopathology. 2020;31(1):41–6. PMID:
Wang Y, Auger M, Kanber Y, Caglar D, Brimo F. Implementing the Paris system for reporting urinary cytology results in a decrease in the rate of the “atypical” category and an increase in its prediction of subsequent high-grade urothelial carcinoma. Cancer Cytopathol. 2018; PMID: 29278461.
Rohilla M, Singh P, Rajwanshi A, Gupta N, Srinivasan R, Dey P, Kakkar N. Cytohistological correlation of urine cytology in a tertiary centre with application of the Paris system. Cytopathology. 2018;29(5):436–43. PMID: 29920811.
Hassan M, Solanki S, Kassouf W, Kanber Y, Caglar D, Auger M, Brimo F. Impact of implementing the Paris system for reporting urine cytology in the performance of urine cytology. Am J Clin Pathol. 2016;146(3):384–90. PMID: 27543983.
Xing J, Monaco S, Pantanowitz L. The ability of the Paris system to stratify the risk of high-grade urothelial carcinoma. J Am Soc Cytopathol [Internet]. Elsevier Inc; 2018;7(5):S43. Aveailable from: https://doi.org/10.1016/j.jasc.2018.06.102.
Nguyen L, Nilforoushan N, Krane JF, Bose S, Bakkar R. Should "suspicious for high-grade urothelial carcinoma" and "positive for high-grade urothelial carcinoma" remain separate categories?. Cancer Cytopathol. 2020. PMID: 33036060.
Zare S, Mirsadraei L, Reisian N, Liao X, Roma A, Shabaik A, Hasteh F. A single institutional experience with the Paris system for reporting urinary cytology: correlation of cytology and histology in 194 cases. Am J Clin Pathol. 2018;150(2):162–7. PMID: 29878037.
Granados R, Duarte JA, Corrales T, Camarmo E, Bajo P. Applying the Paris system for reporting urine cytology increases the rate of atypical urothelial cells in benign cases: a need for patient management recommendations. Acta Cytol. 2017;61(1):71–6. PMID: 27838683.
Brimo F, Xu B, Kassouf W, Ahmadi-Kaliji B, Charbonneau M, Nahal A, Kanber Y, Caglar D, Auger M. Urine cytology: does the number of atypical urothelial cells matter? A qualitative and quantitative study of 112 cases. J Am Soc Cytopathol. 2015;4(4):232–8. PMID: 31051759.
McCroskey Z, Bahar B, Hu Z, Wojcik E, Barkan G. Subclassifying atypia in urine cytology: what are the helpful features? J Am Soc Cytopathol. 2015;4(4):183–9. PMID: 31051752.
Daniel F. I. Kurtycz, Fadi Brimo, Dorothy L. Rosenthal, Momin T. Siddiqui, Z. Laura Tabatabai, Christopher J. VandenBussche, Eva M. Wojcik, Güliz A. Barkan, Perceptions of Paris: An international survey in preparation for The Paris System for Reporting Urinary Cytology 2.0 (TPS 2.0), accepted, American Society of Cytopathology’s 66rd Annual Scientific Meeting, Las Vegas, Nevada, November 11–14, 2021.
Meilleroux J, Daniel G, Aziza J, d’Aure DM, Quintyn-Ranty ML, Basset CML, Evrard SM, Courtade-Saidi MM. One year of experience using the Paris system for reporting urinary cytology. Cancer Cytopathol. 2018;126(6):430–6. PMID: 29663682.
Bakkar R, Mirocha J, Fan X, Frishberg DP, Peralta-Venturina M, de Zhai J, Bose S. Impact of the Paris system for reporting urine cytopathology on predictive values of the equivocal diagnostic categories and interobserver agreement. Cytojournal. 2019;16:21.
Pastorello RG, Barkan GA, Saieg M. Experience on the use of The Paris System for Reporting Urinary Cytopathology: review of the published literature. J Am Soc Cytopathol. 2020:S2213–2945(20)30323–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Brimo, F. et al. (2022). Suspicious for High-Grade Urothelial Carcinoma (SHGUC). In: Wojcik, E.M., Kurtycz, D.F., Rosenthal, D.L. (eds) The Paris System for Reporting Urinary Cytology. Springer, Cham. https://doi.org/10.1007/978-3-030-88686-8_5
Download citation
DOI: https://doi.org/10.1007/978-3-030-88686-8_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-88685-1
Online ISBN: 978-3-030-88686-8
eBook Packages: MedicineMedicine (R0)