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Two Possible AI-Related Paths forĀ Bottom-Up Synthetic Cell Research

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Artificial Life and Evolutionary Computation (WIVACE 2021)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1722))

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Abstract

Advancements in bottom-up synthetic biology (i.e., constructing synthetic cells from scratch) pave the way to new and yet unexplored directions, like: (i) the exploration of semantic aspects of chemical information processing, and (ii) the potential reciprocal inspiration that comes from AI methods and systemic (bio)chemical computation.

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Notes

  1. 1.

    We refer to scenarios whereby properly built SCs act as smart nanomachine for the production of therapeutics via chemical synthesis, inside a biological body. Thanks to their artificially built cognitive traits, SCs could recognize and interact with natural cells via communicative operations. Their entire behavior would result intelligent, due to the capacity of correctly interpreting their surroundings.

References

  1. Bitbol, M., Luisi, P.L.: Autopoiesis with or without cognition: defining life at its edge. J. R. Soc. Interface 1(1), 99ā€“107 (2004). https://doi.org/10.1098/rsif.2004.0012

    ArticleĀ  Google ScholarĀ 

  2. Damiano, L., Hiolle, A., CaƱamero, L.: Grounding synthetic knowledge. In: Lenaerts, T., Giacobini, M., Bersini, H., Bourgine, P., Dorigo, M., Doursat, R. (eds.) Advances in Artificial Life, ECAL 2011, pp. 200ā€“207. MIT Press, Cambridge (2011)

    Google ScholarĀ 

  3. Damiano, L., Stano, P.: Synthetic biology and artificial intelligence. grounding a cross-disciplinary approach to the synthetic exploration of (embodied) cognition. Complex Syst. 27, 199ā€“228 (2018). https://doi.org/10.25088/ComplexSystems.27.3.199

  4. Damiano, L., Stano, P.: On the ā€œlife-likeness" of synthetic cells. Front. Bioeng. Biotechnol. 8, 953 (2020). https://doi.org/10.3389/fbioe.2020.00953

  5. Damiano, L., Stano, P.: A wetware embodied AI? Towards an autopoietic organizational approach grounded in synthetic biology. Front. Bioeng. Biotechnol. 9, 873 (2021). https://doi.org/10.3389/fbioe.2021.724023

    ArticleĀ  Google ScholarĀ 

  6. Hanczyc, M.M., Ikegami, T.: Chemical basis for minimal cognition. Artif. Life 16(3), 233ā€“243 (2010). https://doi.org/10.1162/artl_a_00002

    ArticleĀ  Google ScholarĀ 

  7. Ivanov, I., et al.: Bottom-up synthesis of artificial cells: recent highlights and future challenges. Annu. Rev. Chem. Biomol. Eng. 12(1), 287ā€“308 (2021). https://doi.org/10.1146/annurev-chembioeng-092220-085918

    ArticleĀ  Google ScholarĀ 

  8. Lentini, R., et al.: Two-way chemical communication between artificial and natural cells. ACS Cent. Sci. 3(2), 117ā€“123 (2017). https://doi.org/10.1021/acscentsci.6b00330

    ArticleĀ  Google ScholarĀ 

  9. Logan, R.K.: What is information?: Why is it relativistic and what is its relationship to materiality, meaning and organization. Information 3(1), 68ā€“91 (2012). https://doi.org/10.3390/info3010068

    ArticleĀ  Google ScholarĀ 

  10. Luisi, P.L.: Toward the engineering of minimal living cells. Anat. Rec. 268(3), 208ā€“214 (2002). https://doi.org/10.1002/ar.10155

    ArticleĀ  Google ScholarĀ 

  11. Luisi, P.L., Varela, F.J.: Self-replicating micelles - a chemical version of a minimal autopoietic system. Origins Life Evol. Biosphere 19(6), 633ā€“643 (1989). https://doi.org/10.1007/BF01808123

    ArticleĀ  Google ScholarĀ 

  12. MacKay, D.M.: Information, Meaning and Organization. MIT Press, Cambridge (1969)

    Google ScholarĀ 

  13. Magarini, M., Stano, P.: Synthetic cells engaged in molecular communication: an opportunity for modelling shannon- and semantic-information in the chemical domain. Front. Commun. Netw. 2, 48 (2021). https://doi.org/10.3389/frcmn.2021.724597

    ArticleĀ  Google ScholarĀ 

  14. Maturana, H.R., Varela, F.J.: Autopoiesis and Cognition: The Realization of the Living. D. Reidel Publishing Company (1980)

    Google ScholarĀ 

  15. Pask, G.: An Approach to Cybernetics. Hutchinson & Co., Ltd., London (1961)

    Google ScholarĀ 

  16. Pieters, P.A., et al.: Cell-free characterization of coherent feed-forward loop-based synthetic genetic circuits. ACS Synth. Biol. 10(6), 1406ā€“1416 (2021). https://doi.org/10.1021/acssynbio.1c00024

    ArticleĀ  Google ScholarĀ 

  17. Simon, H.A.: The Sciences of the Artificial. MIT Press, Cambridge (1996)

    Google ScholarĀ 

  18. Szostak, J.W., Bartel, D.P., Luisi, P.L.: Synthesizing life. Nature 409(6818), 387ā€“390 (2001). https://doi.org/10.1038/35053176

    ArticleĀ  Google ScholarĀ 

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Acknowledgements

I am grateful to Prof. Maurizio Magarini (Politecnico di Milano, Milan, Italy) and Prof. Luisa Damiano (IULM, Milan, Italy) for useful discussions.

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Correspondence to Pasquale Stano .

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Stano, P. (2022). Two Possible AI-Related Paths forĀ Bottom-Up Synthetic Cell Research. In: Schneider, J.J., Weyland, M.S., Flumini, D., FĆ¼chslin, R.M. (eds) Artificial Life and Evolutionary Computation. WIVACE 2021. Communications in Computer and Information Science, vol 1722. Springer, Cham. https://doi.org/10.1007/978-3-031-23929-8_9

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  • DOI: https://doi.org/10.1007/978-3-031-23929-8_9

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