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Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

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Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

Part of the book series: Progress in Drug Research ((PDR,volume 70))

Abstract

Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions . This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India . This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis . CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

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Authors and Affiliations

  1. M/P Biomedical Consultants LLC, 402 Live Oak Drive, Mill Valley, CA, 94941, USA

    Michael C. Powanda

  2. School of Medicine, Griffith University, POB 68 Stones Corner, Gold Coast, QLD, 4120, Australia

    Michael W. Whitehouse

  3. Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK

    K D. Rainsford

Authors
  1. Michael C. Powanda
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  2. Michael W. Whitehouse
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  3. K D. Rainsford
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Correspondence to Michael C. Powanda .

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Editors and Affiliations

  1. Sheffield Hallam University Biomedical Res. Centre, Sheffield, United Kingdom

    K. D. Rainsford

  2. M/P Biomedical Consultants, Mill Valley, California, USA

    M. C. Powanda

  3. School of Medicine, Griffith University, Gold Coast, Queensland, Australia

    M. W. Whitehouse

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Powanda, M.C., Whitehouse, M.W., Rainsford, K.D. (2015). Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities. In: Rainsford, K., Powanda, M., Whitehouse, M. (eds) Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases. Progress in Drug Research, vol 70. Springer, Basel. https://doi.org/10.1007/978-3-0348-0927-6_4

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