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Microfluidic Systems with Functional Patterned Surface for Biomedical Applications

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Design of Polymeric Platforms for Selective Biorecognition

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Abstract

In the past decades, microfluidic systems become a promising technology for biomedical applications due to the recent intensive developments. Entire analytical protocol starting from sample pretreatment, sample/reagent manipulation, separation, reaction, detection, to analytical result display can be automatically conducted in such a single compact device. In order to further improve the analytical performance, consideration of functional patterned surfaces is necessary for specific and sensitive analyses. The aim of this chapter is to review recent developments of surface modification technologies in microfluidics. Based on the capability of the biorecognition, in-depth discussions of their biomedical applications including fluid manipulation, suppression of biomolecule adsorption, control of cellular behavior, and biosensing are provided. The current excellent combination of microfluidic technology and surface chemistry suggests a solid foundation for the development of practical biomedical applications.

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Authors and Affiliations

  1. Graduate Institute of Medical Mechatronics, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan 333

    Kin Fong Lei

  2. Department of Mechanical Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan

    Kin Fong Lei

  3. Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan

    I-Chi Lee

  4. Department of Electrical Engineering, University of Colorado Denver, Denver, USA

    Tim C. Lei

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Correspondence to Kin Fong Lei .

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  1. Institute of Polymer Science &Technology, Madrid, Spain

    Juan Rodríguez-Hernández

  2. IMDEA Nanociencia and CNB-CSIC-IMDEA Nanociencia Associated Unit “Unidad Nanobiotecnología”, Madrid, Spain

    Aitziber L. Cortajarena

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Lei, K., Lee, IC., Lei, T. (2015). Microfluidic Systems with Functional Patterned Surface for Biomedical Applications. In: Rodríguez-Hernández, J., Cortajarena, A. (eds) Design of Polymeric Platforms for Selective Biorecognition. Springer, Cham. https://doi.org/10.1007/978-3-319-17061-9_11

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