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Non-linear Dynamics in Transcriptional Regulation: Biological Logic Gates

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Nonlinear Dynamics in Biological Systems

Part of the book series: SEMA SIMAI Springer Series ((SEMA SIMAI,volume 7))

Abstract

Gene expression relies on the interaction of numerous transcriptional signals at the promoter to elicit a response—to read or not to read the genomic code, and if read, the strength of the read. The interplay of transcription factors can be viewed as nonlinear dynamics underlying the biological complexity. Here we analyse the regulation of the cyclooxygenase 2 promoter by NF-κB using thermostatistical and quantitative kinetic modelling and propose the presence of a genetic Boolean AND logic gate controlling the differential expression of cyclooxygenase 2 among species.

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Author information

Authors and Affiliations

  1. Center for the Ecological Study of Perception and Action, University of Connecticut, Storrs, CT, 06269, USA

    Till D. Frank

  2. Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 2780-156, Oeiras, Portugal

    Miguel A. S. Cavadas

  3. Systems Biology Ireland, University College Dublin, Dublin 4, Ireland

    Lan K. Nguyen

  4. Life and Health Science, Aston University, Birmingham, B4 7ET, UK

    Alex Cheong

Authors
  1. Till D. Frank
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  2. Miguel A. S. Cavadas
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  3. Lan K. Nguyen
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  4. Alex Cheong
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Corresponding author

Correspondence to Alex Cheong .

Editor information

Editors and Affiliations

  1. Université Libre de Bruxelles, Brussels, Brussels Hoofdst.ge., Belgium

    Jorge Carballido-Landeira

  2. Basque Center for Applied Mathematics, Bilbao, Spain

    Bruno Escribano

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Frank, T.D., Cavadas, M.A.S., Nguyen, L.K., Cheong, A. (2016). Non-linear Dynamics in Transcriptional Regulation: Biological Logic Gates. In: Carballido-Landeira, J., Escribano, B. (eds) Nonlinear Dynamics in Biological Systems. SEMA SIMAI Springer Series, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-33054-9_3

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