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Do Dietary Factors Influence Tendon Metabolism?

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Metabolic Influences on Risk for Tendon Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 920))

Abstract

There is very little direct research to conclusively prove the relevance of diet in primary tendinopathies, however it seems prudent to ask whether our current knowledge about the impact of nutrition on collagen metabolism could be useful in assessing, preventing, or treating tendinopathy. The objective of this chapter is to discuss the potential impact (negative or positive) that nutrition may have on the metabolism of tendons by summarizing the related research. The chapter briefly discusses the roles that specific vitamins, amino acids, lipids, and antioxidants have in various processes of the body that may be directly or indirectly related to tenocyte metabolism.

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Abbreviations

OA:

Osteoarthritis

IGF-1:

Insulin-like Growth Factor-1

TGF-beta:

Transforming Growth Factor-Beta

FGF2:

Fibroblast Growth Factor 2

COL1A1:

Collagen, type 1, alpha 1

rER:

Rough Endoplasmic Reticulum

MMP1:

Matrix Metalloproteinase-1

PGE2:

Prostaglandin E2

IL1:

Interleukin-1

UV Light:

Ultraviolet Light

LDL:

Low-density Lipoprotein

oxLDL:

Oxidized Low-density Lipoprotein

COL3A1:

Collagen, type 3, alpha 1

MMP2:

Matrix Metalloproteinase-2

ROS:

Reactive Oxygen Species

GTE:

Green Tea Extract

mRNA:

Messenger RibonucleicAcid

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Authors and Affiliations

  1. Department of Physical Therapy, Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada

    Alex Scott & Cara Nordin

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  1. Alex Scott
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  2. Cara Nordin
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Correspondence to Alex Scott .

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Editors and Affiliations

  1. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

    Paul W. Ackermann

  2. McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada

    David A. Hart

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Scott, A., Nordin, C. (2016). Do Dietary Factors Influence Tendon Metabolism?. In: Ackermann, P., Hart, D. (eds) Metabolic Influences on Risk for Tendon Disorders. Advances in Experimental Medicine and Biology, vol 920. Springer, Cham. https://doi.org/10.1007/978-3-319-33943-6_27

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