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Imaging of Tumor Metabolism Using Positron Emission Tomography (PET)

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Metabolism in Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 207))

Abstract

Molecular imaging employing PET/CT enables in vivo visualization, characterization, and measurement of biologic processes in tumors at a molecular and cellular level. Using specific metabolic tracers, information about the integrated function of multiple transporters and enzymes involved in tumor metabolic pathways can be depicted, and the tracers can be directly applied as biomarkers of tumor biology. In this review, we discuss the role of F-18-fluorodeoxyglucose (FDG) as an in vivo glycolytic marker which reflects alterations of glucose metabolism in cancer cells. This functional molecular imaging technique offers a complementary approach to anatomic imaging such as computed tomography (CT) and magnetic resonance imaging (MRI) and has found widespread application as a diagnostic modality in oncology to monitor tumor biology, optimize the therapeutic management, and guide patient care. Moreover, emerging methods for PET imaging of further biologic processes relevant to cancer are reviewed, with a focus on tumor hypoxia and aberrant tumor perfusion. Hypoxic tumors are associated with poor disease control and increased resistance to cytotoxic and radiation treatment. In vivo imaging of hypoxia, perfusion, and mismatch of metabolism and perfusion has the potential to identify specific features of tumor microenvironment associated with poor treatment outcome and, thus, contribute to personalized treatment approaches.

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Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Medical School, Otto-von-Guericke University, Magdeburg A.ö.R., Magdeburg, Germany

    Ivayla Apostolova

  2. Department of Nuclear Medicine, University Medicine Charité, Berlin, Germany

    Florian Wedel & Winfried Brenner

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  1. Ivayla Apostolova
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  2. Florian Wedel
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  3. Winfried Brenner
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Correspondence to Winfried Brenner .

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  1. RWTH University Hospital, Molecular Tumor Biology, Pauwelsstrasse 30, 52074 , Aachen, Germany

    Thorsten Cramer

  2. Dept. of Hematology and Oncology, Charité, Berlin, Germany

    Clemens A. Schmitt

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Apostolova, I., Wedel, F., Brenner, W. (2016). Imaging of Tumor Metabolism Using Positron Emission Tomography (PET). In: Cramer, T., A. Schmitt, C. (eds) Metabolism in Cancer. Recent Results in Cancer Research, vol 207. Springer, Cham. https://doi.org/10.1007/978-3-319-42118-6_8

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