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Dietary Restriction in C. elegans

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Ageing: Lessons from C. elegans

Part of the book series: Healthy Ageing and Longevity ((HAL))

Abstract

Ageing increases risk for multiple chronic diseases. Dietary restriction (DR), reducing food intake without malnutrition, is a potent intervention that delays ageing and onset of age-related diseases from yeast to mammals. Research using model organisms such as C. elegans can therefore be used to elucidate mechanisms underpinning DR that might have therapeutic potential. In this chapter, we discuss the advantages and disadvantages of using C. elegans to study how DR modulates healthy ageing. We provide a comprehensive summary on the different methods of DR used to date, and the effects of DR on healthspan and models of age-related diseases. We focus on the molecular mechanisms and physiological processes used by DR to promote longevity, highlighting advantages of using C. elegans as a model to discover novel mechanisms that can be translated to anti-ageing interventions in humans.

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Acknowledgements

We thank members of the Mair lab for helpful discussion and critical reading of the manuscript. We would like to apologize to those whose work could not be cited here due to space limitations. W.M. is funded by the Ellison Medical Foundation and the NIH/NIA R01AG044346.

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  1. Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA

    Yue Zhang & William B. Mair

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  1. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Anders Olsen

  2. Department of Metabolics & Aging, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, USA

    Matthew S. Gill

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Zhang, Y., Mair, W.B. (2017). Dietary Restriction in C. elegans . In: Olsen, A., Gill, M. (eds) Ageing: Lessons from C. elegans. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-44703-2_16

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