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Immunodeficiency in Bronchiectasis

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Bronchiectasis

Abstract

Immune deficiency is the third most commonly identified cause for bronchiectasis, after cystic fibrosis and postinfectious bronchiectasis, in children and adults. In this chapter we describe primary and secondary immune deficiencies that are commonly complicated by bronchiectasis including specific investigations required to make these diagnoses. We focus on antibody deficiency which is the most common immune deficiency identified in bronchiectasis. Key investigations that should be performed on all idiopathic bronchiectatic patients are outlined. Finally, we describe the management of bronchiectasis in immune-deficient patients including recommendations on immunisation, antibiotic prophylaxis, immunoglobulin replacement therapy, joint respiratory-immunology care clinics and long-term monitoring.

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Author information

Authors and Affiliations

  1. Regional Immunology Service, The Royal Hospitals, Belfast, UK

    Tanya I. Coulter, Lisa Devlin & J. David M. Edgar

  2. Belfast Health and Social Care Trust, Belfast, UK

    Damian Downey

  3. Queen’s University of Belfast, Belfast, UK

    Damian Downey & J. Stuart Elborn

  4. Imperial College and Royal Brompton Hospital, London, UK

    J. Stuart Elborn

Authors
  1. Tanya I. Coulter
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  2. Lisa Devlin
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  3. Damian Downey
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  4. J. Stuart Elborn
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  5. J. David M. Edgar
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Correspondence to Tanya I. Coulter .

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Editors and Affiliations

  1. College of Medicine, University of Dundee , Dundee, United Kingdom

    James Chalmers

  2. Hospital Vall D’Hebron, Vall D’Hebron Research Institute (VHIR) Respiratory Disease Department, Barcelona, Spain

    Eva Polverino

  3. Department of Pathophysiology and Transplantation, University of Milan Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Stefano Aliberti

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Coulter, T.I., Devlin, L., Downey, D., Elborn, J.S., Edgar, J.D.M. (2018). Immunodeficiency in Bronchiectasis. In: Chalmers, J., Polverino, E., Aliberti, S. (eds) Bronchiectasis. Springer, Cham. https://doi.org/10.1007/978-3-319-61452-6_7

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