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G-Protein-Coupled Receptors: Membrane Diffusion and Organization Matter

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Membrane Organization and Dynamics

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 20))

Abstract

G-protein coupled receptors constitute an important family of membrane proteins. They are involved in numerous signaling pathways. The efficiency and regulation of these signaling events depend on the organization of the receptors with their different partners in the plasma membrane, and the way this organization influences the encounters between them. By studying the dynamics of the receptors and their partners in the plasma membrane, important information can be obtained on this membrane organization. In this chapter, we will first review experimental techniques used to study receptor dynamics. Then we discuss how the membrane environment influences receptor dynamics, and how measurements of this dynamics can inform us on interactions of the receptors with their signaling partners and on the effect of ligands. We finish by discussing recent theoretical advances on models of receptor organization, in particular the cluster phases, which provide a coherent framework for the understanding of this organization.

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  1. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France

    Evert Haanappel & Laurence Salomé

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  2. Laurence Salomé
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Correspondence to Laurence Salomé .

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  1. Centre for Cellular & Molecular Biology , Hyderabad, India

    Amitabha Chattopadhyay

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Haanappel, E., Salomé, L. (2017). G-Protein-Coupled Receptors: Membrane Diffusion and Organization Matter. In: Chattopadhyay, A. (eds) Membrane Organization and Dynamics . Springer Series in Biophysics, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-319-66601-3_11

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