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Carriers in the Topical Treatment of Skin Disease

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Drug Delivery

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 197))

Abstract

Topical drug application is less prone to severe systemic side-effects than systemic application. Starting with the liposomes, various types of nanosized and microsized drug carriers have been developed to increase the notoriously low penetration of active agents into the skin, which limits not only the topical therapy of skin disease but also transdermal therapy. Today, liposome- and microsponge-based preparations are approved for dermatomycosis, acne and actinic keratosis. Under investigation are drug carriers such as lipid nanoparticles, polymeric particles, dendrimers, and dendritic-core multi-shell nanotransporters. According to the rapidly increasing research in this field, both in academia and industry, a breakthrough appears likely, once stability problems (nanoparticles) and safety concerns (dendrimers) are overcome. Technical approaches and results of in vitro, ex vivo and in vivo testing are described, taking into account pharmacokinetic, efficacy and safety aspects.

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Abbreviations

5-FU:

5-Fluorouracil

API:

Active pharmaceutical ingredient

CAT-1:

4-Trimethyl-ammonium-2,2,6,6-tetramethylpiperidine-1-oxyliodide

CMS:

Core multi-shell (nanotransporters)

CNT:

(Carbo-)nanotubes

CPA:

Cyproterone acetate

FITC:

Fluorescein 5-isothiocyanate

GRAS:

Generally recognised as safe

logP :

Octanol:water partition coefficient

MCT:

Medium chain triglycerides

NLC:

Nanostructured lipid carriers

OECD:

Organisation for Economic Co-operation and Development

PLA:

Polylactic acid

PLGA:

Poly(d,l-lactic-co-glycolic acid)

PASI:

Psoriasis Area and Severity Index

QSPR:

Quantitative structure permeability relationship

SCCP:

Scientific Committee on Consumer Products

SLN:

Solid lipid nanoparticles

TAC:

Triamcinolone acetonide

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Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstraße 9-11, 80337, München, Germany

    Hans Christian Korting

  2. Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, Königin-Luise-Straße 2-4, 14195, Berlin, Germany

    Monika Schäfer-Korting

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  1. Hans Christian Korting
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  2. Monika Schäfer-Korting
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Correspondence to Hans Christian Korting or Monika Schäfer-Korting .

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  1. FB Biologie, Chemie, Pharmazie, Inst. Pharmazie, FU Berlin, Königin-Luise-Str. 2-4, Berlin, 14195, Berlin, Germany

    Monika Schäfer-Korting

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Korting, H.C., Schäfer-Korting, M. (2010). Carriers in the Topical Treatment of Skin Disease. In: Schäfer-Korting, M. (eds) Drug Delivery. Handbook of Experimental Pharmacology, vol 197. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00477-3_15

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