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Hair Growth Parameters in Pre- and Postmenopausal Women

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Aging Hair

Abstract

Women who undergo menopause have a cessation of ovarian estrogen production. This dramatic hormonal alteration is known to have significant effects on the skin and cutaneous appendages. As our understanding of the molecular and hormonal controls on the folliculo-sebaceous unit has grown, there has been renewed interest in the role of estrogens in modulating hair growth. Specifically, the relatively recent discovery of estrogen receptor beta has broadened and redefined prior concepts of estrogen activity and signaling. In a cohort of pre- and postmenopausal women without alopecia, a modified phototrichogram was used to measure hair density, growth rate, and percentage anagen. Optical fiber diameter analysis (OFDA) was used to determine hair diameters. Our aim was to determine whether there are any changes in hair characteristics and hair growth parameters that correlate with menopausal status. Postmenopausal women had significant changes, mainly in the frontal scalp as compared to premenopausal women. These changes included lower frontal scalp percent anagen hairs, growth rates, and hair diameters. Further study of hair changes in response to menopause provides an important opportunity for identification of treatments, targets, and strategies that may significantly benefit women.

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References

  1. Barman JM, Astore I, Pecoraro V (1965) The normal trichogram of the adult. J Invest Dermatol 44:233–236

    CAS  PubMed  Google Scholar 

  2. Bergfeld WF (2008) Telogen effluvium. In: Hordinsky MA (ed) Hair and scalp diseases. Informa Healthcare, New York, pp 125

    Google Scholar 

  3. Birch MP, Messenger JF, Messenger AG (2001) Hair density, hair diameter and the prevalence of female pattern hair loss. Br J Dermatol 144:297–304

    Article  CAS  PubMed  Google Scholar 

  4. Birch MP, Lashen H, Agarwal S, Messenger AG (2006) Female pattern hair loss, sebum excretion and the end-organ response to androgens. Br J Dermatol 154:85–89

    Article  CAS  PubMed  Google Scholar 

  5. Chanda S, Robinette CL, Couse JF, Smart RC (2000) 17beta-estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-alpha pathway. Am J Physiol Endocrinol Metab 278:E202–E210

    Google Scholar 

  6. Conrad F, Paus R (2004) Estrogens and the hair follicle. J Dtsch Dermatol Ges 2:412–423

    Article  PubMed  Google Scholar 

  7. Conrad F, Ohnemus U, Bodo E, Biro T, Tychsen B, Gerstmayer B, Bosio A, Schmidt-Rose T, Altgilbers S, Bettermann A, Saathoff M, Meyer W, Paus R (2005) Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocate gender-tailored management of female versus male pattern balding. J Investig Dermatol Symp Proc 10: 243–246

    Article  CAS  PubMed  Google Scholar 

  8. Courtois M, Loussouarn G, Hourseau C, Grollier JF (1995) Ageing and hair cycles. Br J Dermatol 132:86–93

    Article  CAS  PubMed  Google Scholar 

  9. Gassmueller J, Hoffmann R, Webster A (2008) Topical fulvestrant solution has no effect on male and postmenopausal female androgenetic alopecia: results from two randomized, proof-of-concept studies. Br J Dermatol 158:109–115

    CAS  PubMed  Google Scholar 

  10. Hoffmann R, Niiyama S, Huth A, Kissling S, Happle R (2002) 17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo. Exp Dermatol 11: 376–380

    Article  CAS  PubMed  Google Scholar 

  11. Kligman AM (1988) The comparative histopathology of male-pattern baldness and senescent baldness. Clin Dermatol 6:108–118

    Article  CAS  PubMed  Google Scholar 

  12. Kondo S, Hozumi Y, Aso K (1990) Organ culture of human scalp hair follicles: effect of testosterone and oestrogen on hair growth. Arch Dermatol Res 282:442–445

    Article  CAS  PubMed  Google Scholar 

  13. Loussouarn G, El Rawadi C, Genain G (2005) Diversity of hair growth profiles. Int J Dermatol 44 (suppl 1):6–9

    Article  Google Scholar 

  14. Lupton CJ, McColl A, Stobart RH (2006) Fiber characteristics of the Huacaya Alpaca. Small Rumin Res 64:211–224

    Article  Google Scholar 

  15. Lynfield YL (1960) Effect of pregnancy on the human hair cycle. J Invest Dermatol 35:323–327

    Article  CAS  PubMed  Google Scholar 

  16. Moverare S, Lindberg MK, Faergemann J, Gustafsson JA, Ohlsson C (2002) Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the hair follicle cycling as well as the thickness of epidermis in male mice. J Invest Dermatol 119:1053–1058

    Article  CAS  PubMed  Google Scholar 

  17. Muallem MM, Rubeiz NG (2006) Physiological and biological skin changes in pregnancy. Clin Dermatol 24:80–83

    Article  PubMed  Google Scholar 

  18. Nissimov J, Elchalal U (2003) Scalp hair diameter increases during pregnancy. Clin Exp Dermatol 28:525–530

    Article  CAS  PubMed  Google Scholar 

  19. Oh HS, Smart RC (1996) An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc Natl Acad Sci USA 93:12525–12530

    Article  CAS  PubMed  Google Scholar 

  20. Ohnemus U, Unalan M, Handjiski B, Paus R (2004) Topical estrogen accelerates hair regrowth in mice after chemotherapy-induced alopecia by favoring the dystrophic catagen response pathway to damage. J Invest Dermatol 122:7–13

    Article  CAS  PubMed  Google Scholar 

  21. Ohnemus U, Uenalan M, Conrad F, Handjiski B, Mecklenburg L, Nakamura M, Inzunza J, Gustafsson JA, Paus R (2005) Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling. Endocrinology 146:1214–1225

    Article  CAS  PubMed  Google Scholar 

  22. Ohnemus U, Uenalan M, Inzunza J, Gustafsson JA, Paus R (2006) The hair follicle as an estrogen target and source. Endocr Rev 27:677–706

    Article  CAS  PubMed  Google Scholar 

  23. Olsen EA (2001) Female pattern hair loss. J Am Acad Dermatol 45:S70–S80

    Article  Google Scholar 

  24. Olsen EA (2003) Current and novel methods for assessing efficacy of hair growth promoters in pattern hair loss. J Am Acad Dermatol 48:253–262

    Article  PubMed  Google Scholar 

  25. Olsen EA, Hordinsky M, Roberts JL, Whiting DA (2002) Female pattern hair loss. J Am Acad Dermatol 47:795

    Article  PubMed  Google Scholar 

  26. Orfanos CE, Vogels L (1980) Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study (author’s transl). Dermatologica 161: 124–132

    Article  CAS  PubMed  Google Scholar 

  27. Orme S, Cullen DR, Messenger AG (1999) Diffuse female hair loss: are androgens necessary? Br J Dermatol 141: 521–523

    Article  CAS  PubMed  Google Scholar 

  28. Qi K, Lupton CJ, Pfeiffer FA, Minikhiem DL (1994) Evaluation of the optical fibre diameter analyser (OFDA) for measuring fiber diameter parameters of sheep and goats. J Anim Sci 72:1675–1679

    CAS  PubMed  Google Scholar 

  29. Rymer J, Morris EP (2000) “Extracts from “clinical evidence”: menopausal symptoms. BMJ 321:1516–1519

    Article  CAS  PubMed  Google Scholar 

  30. Sawaya ME, Price VH (1997) Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol 109:296–300

    Article  CAS  PubMed  Google Scholar 

  31. Smart RC, Oh HS (1998) On the effect of estrogen receptor agonists and antagonists on the mouse hair follicle cycle. J Invest Dermatol 111:175

    Article  CAS  PubMed  Google Scholar 

  32. Sperling LC (1999) Hair density in African Americans. Arch Dermatol 135:656–658

    Article  CAS  PubMed  Google Scholar 

  33. Stenn KS, Paus R, Filippi M (1998) Failure of topical estrogen receptor agonists and antagonists to alter murine hair follicle cycling. J Invest Dermatol 110:95

    CAS  PubMed  Google Scholar 

  34. Tajima M, Hamada C, Arai T, Miyazawa M, Shibata R, Ishino A (2007) Characteristic features of Japanese women’s hair with aging and with progressing hair loss. J Dermatol Sci 45:93–103

    Article  PubMed  Google Scholar 

  35. Thornton MJ (2005) Oestrogen functions in skin and skin appendages. Expert Opin Ther Targets 9:617–629

    Article  CAS  PubMed  Google Scholar 

  36. Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O’Driscoll J, Messenger AG (2003) Oestrogen receptor beta is the predominant oestrogen receptor in human scalp skin. Exp Dermatol 12:181–190

    Article  CAS  PubMed  Google Scholar 

  37. Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O’Driscoll J, Messenger AG (2003) The distribution of estrogen receptor beta is distinct to that of estrogen receptor alpha and the androgen receptor in human skin and the pilosebaceous unit. J Investig Dermatol Symp Proc 8: 100–103

    Article  CAS  PubMed  Google Scholar 

  38. Van Neste D (2004) Thickness, medullation and growth rate of female scalp hair are subject to significant variation according to pigmentation and scalp location during ageing. Eur J Dermatol 14:28–32

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, The Permanente Medical Group, 975 Sereno Drive, 2nd Floor, Hallway F, Vallejo, CA, 94589, USA

    Paradi Mirmirani

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  1. Paradi Mirmirani
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  2. Fangyi Luo
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  7. Thomas L. Dawson
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Correspondence to Paradi Mirmirani .

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Editors and Affiliations

  1. Dermatologische Klinik, Universitätsspital Zürich, Gloriastr. 31, Zürich, 8091, Switzerland

    Ralph M. Trüeb

  2. Centre for Skin Sciences, University of Bradford, Bradford, W. Yorks., BD7 1DP, United Kingdom

    Desmond J. Tobin

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Mirmirani, P. et al. (2010). Hair Growth Parameters in Pre- and Postmenopausal Women. In: Trüeb, R., Tobin, D. (eds) Aging Hair. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02636-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-02636-2_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02635-5

  • Online ISBN: 978-3-642-02636-2

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