Abstract
The effects of soy on diet and health have been topics of intense research for the last 20 years or more. Much of this research has suggested that soy consumption can have beneficial effects on several aspects of human health. Regular inclusion of soy and/or soy isoflavones in the diet has been reported to modestly improve plasma lipid profiles, improve bone health, reduce menopausal symptoms, enhance cognitive function, and potentially reduce the risk of breast and prostate cancers. The health benefits of dietary soy have been attributed to its isoflavones as well as to the biological actions of its constituent proteins. These potential health benefits of soy consumption have been extensively reviewed elsewhere [9, 30] and will not be discussed in this chapter.
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References
Adlercreutz, H., Bannwart, C., Wahala, K., et al.: Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J. Steroid. Biochem. Mol. Biol. 44, 147–153 (1993)
Akiyama, T., Ishida, J., Nakagawa, S., et al.: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262, 5592–5595 (1987)
Andre-Frei, V., Perrier, E., Augustin, C., et al.: A comparison of biological activities of a new soya biopeptide studied in an in vitro skin equivalent model and human volunteers. Int. J. Cosmet. Sci. 21, 299–311 (1999)
Axelson, M., Sjovall, J., Gustafsson, B.E., et al.: Soya – a dietary source of the non-steroidal oestrogen equol in man and animals. J. Endocrinol. 102, 49–56 (1984)
Bazzoli, D.L., Hill, S., DiSilvestro, R.A.: Soy protein antioxidant actions in active, young adult women. Nutr. Res. 22, 807–815 (2002)
Blair, R.M., Tabor, A.: The beauty of soy for skin, hair and nails. In: Blair, R.M., Tabor, A. (eds.) Nutritional Cosmetics: Beauty from Within. Elsevier, Oxford, UK and Burlington, MA, USA (2009)3
Borras, C., Gambini, J., Gomez-Cabrera, M.C., et al.: Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFκB. FASEB J. 20, E1476–E1481 (2006)
Brand, R.M., Jendrzejewski, J.L.: Topical treatment with (-)-epigallocatechin-3-gallate and genistein after a single UV exposure can reduce skin damage. J. Dermatol. Sci. 50, 69–72 (2008)
Cassidy, A., Albertazzi, P., Nielsen, I.L., et al.: Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women. Proc. Nutr. Soc. 65, 76–92 (2006)
Chan, W.H., Yu, J.S.: Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by genistein. J. Cell. Biochem. 78, 73–84 (2000)
Day, A.J., Canada, F.J., Diaz, J.C., et al.: Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Lett. 468, 166–170 (2000)
Dixon, R.A.: Phytoestrogens. Annu. Rev. Plant Biol. 55, 225–261 (2004)
Draelos, Z., Blair, R., Tabor, A.: Oral soy supplementation and dermatology. Cosmet. Dermatol. 20, 202–204 (2007)
Evans, B.A., Griffiths, K., Morton, M.S.: Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J. Endocrinol. 147, 295–302 (1995)
Harada, N., Okajima, K., Arai, M., et al.: Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-1 production in mice and in humans with alopecia. Growth Horm. IGF Res. 17, 408–415 (2007)
Huang, Z.R., Hung C.F., Lin Y.K., et al.: In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isoflavones genistein and daidzein. Int. J. Pharmaceut. 364, 36–44 (2008) (In Press, doi:10.1016/j.ijpharm.2008.08.002)
Hwang, C.S., Kwak, H.S., Lim, H.J., et al.: Isoflavone metabolites and their in vitro dual functions: they can act as estrogenic agonist or antagonist depending on the estrogen concentration. J. Steroid Biochem. Mol. Biol. 101, 246–253 (2006)
Kahari, V.M., Saaraialho-Kere, U.: Matrix metalloproteinases in skin. Exp. Dermatol. 6, 199–213 (1997)
Kim, S.Y., Kim, S.J., Lee, J.Y., et al.: Protective effects of dietary soy isoflavones against UV-induced skin-aging in hairless mouse model. J. Am. Coll. Nutr. 23, 157–162 (2004)
Kuiper, G.G.J.M., Lemmen, J.G., Carlsson, B., et al.: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139, 4252–4263 (1998)
Le Bail, J.C., Champavier, Y., Chulia, A.J., et al.: Effects of phytoestrogens on aromatase, 3β and 17β-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Sci. 66, 1281–1291 (2000)
Leyden, J.J., Nebus, J., Wallo, W.: Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study. J. Drugs Dermatol. 6, 917–922 (2007)
Lin, J.Y., Tournas, J.A., Burch, J.A., et al.: Topical isoflavones provide effective photoprotection to skin. Photodermatol. Photoimmunol. Photomed. 24, 61–66 (2008)
Liu, Z., Lu, Y., Lebwohl, M., et al.: PUVA (8-methoxy-psoralen plus ultraviolet A) induces the formation of 8-hydroxy-2′-deoxyguanosine and DNA fragmentation in calf thymus DNA and human epidermoid carcinoma cells. Free. Radic. Biol. Med. 27, 127–133 (1999)
Makela, S., Poutanen, M., Lehtimaki, J., et al.: Estrogen-specific 17 beta-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens. Proc. Soc. Exp. Biol. 208, 51–59 (1995)
McCarty, M.F.: Isoflavones made simple – genistein’s agonist activity for the beta-type estrogen receptor mediates their health benefits. Med. Hypotheses 66, 1093–1114 (2006)
McElwee, K.J., Niiyama, S., Freyschmidt-Paul, P., et al.: Dietary soy oil content and soy-derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice. Exp. Dermatol. 12, 30–36 (2003)
Moore, J.O., Wang, Y., Stebbins, W.G., et al.: Photoprotective effect of isoflavone genistein on ultraviolet B induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis. Carcinogenesis 27, 1627–1635 (2006)
Morito, K., Hirose, T., Kinjo, J., et al.: Interaction of phytoestrogens with estrogen receptors α and β. Biol. Pharm. Bull. 24, 351–356 (2001)
Omoni, A.O., Aluko, R.E.: Soybean foods and their benefits: potential mechanisms of action. Nutr. Rev. 63, 272–283 (2005)
Pelissero, C., Lenczowski, M.J.P., Chinzi, D., et al.: Effects of flavonoids on aromatase activity, an in vitro study. J. Steroid. Biochem. Mol. Biol. 57, 215–223 (1996)
Reeve, V.E., Widyarini, S., Domanski, D., et al.: Protection against photoaging in the hairless mouse by the isoflavone equol. Photochem. Photobiol. 81, 1548–1553 (2005)
Rowland, I., Faughnan, M., Hoey, L., et al.: Bioavailability of phyto-oestrogens. Br. J. Nutr. 89(Suppl 1), S45–S58 (2003)
Rufer, C.E., Kulling, S.E.: Antioxidant activity of isoflavones and their major metabolites using different in vitro assays. J. Agric. Food Chem. 54, 2926–2931 (2006)
Seiberg, M., Liu, J.C., Babiarz, L., et al.: Soymilk reduces hair growth and hair follicle dimensions. Exp. Dermatol. 10, 405–413 (2001)
Setchell, K.D.R.: Soy isoflavones – benefits and risks from nature’s selective estrogen receptor modulators. J. Am. Coll. Nutr. 20, 354S–362S (2001)
Setchell, K.D., Borriello, S.P., Hulme, P., et al.: Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am. J. Clin. Nutr. 40, 569–578 (1984)
Setchell, K.D., Brown, N.M., Zimmer-Nechemias, L., et al.: Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am. J. Clin. Nutr. 76, 447–453 (2002)
Setchell, K.D., Brown, N.M., Lydeking-Olsen, E.: The clinical importance of the metabolite equol – a clue to the effectiveness of soy and its isoflavones. J. Nutr. 132, 3577–3584 (2002)
Shyong, E.Q., Lu, Y., Lazinsky, A., et al.: Effects of the isoflavone 4’, 5, 7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage. Carcinogenesis 23, 317–321 (2002)
Sudel, K.M., Venzke, K., Mielke, H., et al.: Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. Photochem. Photobiol. 81, 581–587 (2005)
Trompezinski, S., Denis, A., Schmitt, D., et al.: Comparative effects of polyphenols from green tea (EGCG) and soybean (genistein) on VEGF and IL-8 release from normal human keratinocytes stimulated with the proinflammatory cytokine TNFα. Arch. Dermatol. Res. 295, 112–116 (2003)
Tsuruki, T., Takahata, K., Yoshikawa, M.: A soy-derived immunostimulating peptide inhibits etoposide-induced alopecia in neonatal rats. J. Invest. Dermatol. 122, 848–850 (2004)
Tsuruki, T., Takahata, K., Yoshikawa, M.: Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy b-conglycinin. Peptides 26, 707–711 (2005)
Varani, J., Kelley, E.A., Perone, P., et al.: Retinoin-induced epidermal hyperplasia in human skin organ culture: inhibition with soy extract and soy isoflavones. Exp. Mol. Pathol. 77, 176–183 (2004)
Vega-Lopez, S., Yeum, K.J., Lecker, J.L., et al.: Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones. Am. J. Clin. Nutr. 81, 43–49 (2005)
Wang, H.J., Murphy, P.A.: Isoflavone content in commercial soybean foods. J. Agric. Food Chem. 42, 1666–1673 (1994)
Wang, H.J., Murphy, P.A.: Isoflavone composition of American and Japanese soybeans in Iowa: effects of variety, crop year, and location. J. Agric. Food Chem. 42, 1674–1677 (1994)
Wang, Y., Yaping, E., Zhang, X., et al.: Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor, genistein. Carcinogenesis 19, 649–654 (1998)
Wei, H., Bowen, R., Zhang, X., et al.: Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogenesis 19, 1509–1514 (1998)
Wei, H., Saladi, R., Lu, Y., et al.: Isoflavone genistein: photoprotection and clinical implications in dermatology. J. Nutr. 133, 3811S–3819S (2003)
Widyarini, S.: Protective effect of the isoflavone equol against DNA damage induced by ultraviolet radiation to hairless mouse skin. J. Vet. Sci. 7, 217–223 (2006)
Widyarini, S., Spinks, N., Husband, A.J., et al.: Isoflavonoid compounds from red clover (Trifolium pratense) protect from inflammation and immune suppression induced by UV radiation. Photochem. Photobiol. 74, 465–470 (2001)
Widyarini, S., Husband, A.J., Reeve, V.E.: Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical co-carcinogen. Photochem. Photobiol. 81, 32–37 (2005)
Widyarini, S., Allanson, M., Gallagher, N.L., et al.: Isoflavonoid photoprotection in mouse and human skin is dependent on metallothionein. J. Invest. Dermatol. 126, 198–204 (2006)
Wiseman, H., O’Reilly, J.D., Adlercreutz, H., et al.: Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am. J. Clin. Nutr. 72, 395–400 (2000)
Wu, H.J., Chan, W.H.: Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells. Toxicol. In Vitro 21, 335–342 (2007)
Xu, X., Harris, K.S., Wang, H.J., et al.: Bioavailability of soybean isoflavones depends upon gut microflora in women. J. Nutr. 125, 2307–2315 (1995)
Yuan, J.P., Wang, J.H., Liu, X.: Metabolism of dietary soy isoflavones to equol by human intestinal microflora – implications for health. Mol. Nutr. Food Res. 51, 765–781 (2007)
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Blair, R.M., Tabor, A. (2010). Potential Benefits of Soy for Skin, Hair, and Nails. In: Krutmann, J., Humbert, P. (eds) Nutrition for Healthy Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12264-4_10
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