Abstract
DNA 3D nanostructures have the promising features to be the universal nanocarriers for smart or targeted drug delivery. In this chapter, we will review recent works on using DNA nanotube, DNA tetrahedron, DNA origami nanotube, and DNA origami nanorobot as drug delivery nanocarriers. Their researches showed that specially designed DNA 3D nanostructures, especially DNA tetrahedron, demonstrated great cell uptaking efficacy and are stable for both in vitro and in vivo drug delivery purpose. The exploratory works on DNA 3D nanocarriers assisted the study on cytosine-phosphate-guanine (CpG)-induced immunostimulation, and SiRNA gene silencing paved the way for DNA 3D nanostructures’ real therapeutic application.
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References
Farokhzad OC, Langer R (2009) Impact of nanotechnology on drug delivery. ACS Nano 3:16–20
Chhabra R, Sharma J, Liu Y, Rinker S, Yan H (2010) DNA self-assembly for nanomedicine. Adv Drug Deliv Rev 62:617–625
Roh YH, Ruiz RCH, Peng S, Lee JB, Luo D (2011) Engineering DNA-based functional materials. Chem Soc Rev 40:5730–5744
Ko SH, Liu H, Chen Y, Mao C (2008) DNA nanotubes as combinatorial vehicles for cellular delivery. Biomacromolecules 9:3039–3043
Mathieu F, Liao S, Kopatsch J, Wang T, Mao C, Seeman NC (2005) Six-helix bundles designed from DNA. Nano Lett 5:661–665
Wang R, Liu W, Seeman NC (2009) Prototyping nanorod control: a DNA double helix sheathed within a DNA six-helix bundle. Chem Biol 16:862–867
Keuma JW, Bermudez H (2009) Enhanced resistance of DNA nanostructures to enzymatic digestion. Chem Commun 45:7036–7038
Goodman RP, Berry RM, Turberfield AJ (2004) The single-step synthesis of a DNA tetrahedron. Chem Commun 40:1372–1373
Goodman RP, Schaap IAT, Tardin CF, Erben CM, Berry RM, Schmidt CF, Turberfield AJ (2005) Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science 310:1661–1665
Walsh AS, Yin H, Erben CM, Wood MJA, Turberfield AJ (2011) DNA cage delivery to mammalian cells. ACS Nano 5:5427–5432
Li J, Pei H, Zhu B, Liang L, Wei M, He Y, Chen N, Li D, Huang Q, Fan C (2011) Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. ACS Nano 5:8783–8789
Lee H, Lytton-Jean AKR, Chen Y, Love KT, Park AI, Karagiannis ED, Sehgal A, Querbes W, Zurenko CS, Jayaraman M, Peng CG, Charisse K, Borodovsky A, Manoharan M, Donahoe JS, Truelove J, Nahrendorf M, Langer R, Anderson DG (2012) Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo SiRNA delivery. Nat Nanotechnol 7:389–393
He Y, Ye T, Su M, Zhang C, Ribbe AE, Jiang W, Mao C (2008) Hierarchical self-assembly of DNA into symmetric supramolecular polyhedral. Nature 452:198–202
Li Z, Wei B, Nangreave J, Lin C, Liu Y, Mi Y, Yan H (2009) A replicable tetrahedral nanostructure self-assembled from a single DNA strand. J Am Chem Soc 131:13093–13098
Goodman RP, Heilemann M, Doose S, Erben CM, Kapanidis AN, And Turberfield AJ (2008) Reconfigurable, braced, three dimensional DNA nanostructures. Nat Nanotechnol 3:93–96
Mei Q, Wei X, Su F, Liu Y, Youngbull C, Johnson R, Lindsay S, Yan H, Meldrum D (2011) Stability of DNA origami nanoarrays in cell lysate. Nano Lett 11:1477–1482
Schuller VJ, Heidegger S, Sandholzer N, Nickels PC, Suhartha NA, Endres S, Bourquin C, Liedl T (2011) Cellular immunostimulation by CpGSequence- coated DNA origami structures. ACS Nano 5:9696–9702
Andersen ES, Dong M, Nielsen MM, Jahn K, Subramani R, Mamdouh W, Golas MM, Sander B, Stark H, Oliveira CLP, Pedersen JS, Birkedal V, Besenbacher F, Gothelf KV, Kjems J (2009) Self-assembly of a nanoscale DNA box with a controllable lid. Nature 459:73–77
Douglas SM, Bachelet I, Church GM (2012) A logic-gated nanorobot for targeted transport of molecular payloads. Science 335:831–834
Fu J, Yan H (2012) Controlled drug release by a nanorobot. Nat Biotechnol 30:407–408
Ke Y, Sharma J, Liu M, Jahn K, Liu Y, Yan H (2009) Scaffolded DNA origami of a DNA tetrahedron molecular container. Nano Lett 9:2445–2447
Rinker S, Liu Y, Yan H (2006) Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex. Chem Commun 42:2675–2677
Shen W, Bruist MF, Goodman SD, Seeman NC (2004) A protein-driven DNA device that measures the excess binding energy of proteins that distort DNA. Angew Chem Int Ed 43:4750–4752
Delebecque CJ, Lindner AB, Silver PA, Aldaye FA (2011) Organization of intracellular reactions with rationally designed RNA assemblies. Science 333:470–474
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Shen, W. (2013). DNA Nanotechnology and Drug Delivery. In: Fan, C. (eds) DNA Nanotechnology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36077-0_15
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DOI: https://doi.org/10.1007/978-3-642-36077-0_15
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