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Pathological and Physiological Factors Affecting Drug Absorption, Distribution, Elimination, and Response in Man

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Concepts in Biochemical Pharmacology

Abstract

Although drugs are used primarily for the treatment of disease, surprisingly little is known of the way in which disease states or physiological factors modify drug action in man. In contrast, extensive studies in laboratory animals have shown that these factors can have striking effects which if applied to man would have enormous clinical significance. The failure to apply this basic knowledge to clinical medicine amounts virtually to negligence on the part of the medical profession.

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  1. L. F. Prescott
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  1. Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, USA

    James R. Gillette  & Jerry R. Mitchell  & 

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Prescott, L.F. (1975). Pathological and Physiological Factors Affecting Drug Absorption, Distribution, Elimination, and Response in Man. In: Gillette, J.R., Mitchell, J.R. (eds) Concepts in Biochemical Pharmacology. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 28 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46314-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-46314-3_9

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