Abstract
The indication for the use of cytostatic substances has been expanded significantly by the knowledge that almost without exception cytostatic agents exert an immunosuppressive effect. At present, the clinical importance of this property is nearly equal to their actual cytostatic effects. The frequency in the use made of cytostatic agents is in noticeable contrast to our limited knowledge of their mode of action. On account of this the choice of the respective agent, the time of its administration, the combination possibilities of various substances which act in a similar manner is largely left to coincidence or to the experience of the individual physician.
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Boggs, D. R., J. W. Athens, O. P. Haab, P. A. Cancilla, S. O. Raab, G. E. Cartwright, and M. W. Wintrobe: Leukokinetic studies. VII. Morphology of the bone marow and blood of dogs given vinblastine sulfate. Blood 23, 53 (1964).
Bruce, W. R., B. E. Meeker, and F. A. Valeriote: Comparison of the sensitivity of normal hematopoietic and transplanted Lymphoma colony-forming cells to chemotherapeutic agents administred in-vivo. J. nat. Cancer Inst. 37, 233 (1966).
Bruchovsky, N., A. A. Owen, A. J. Becker, and J. E. Till: Effects of vinblastine on the proliferative capacity of L-cells and their progress through the division cycle. Cancer Res. 25, 1232 (1965).
Hersh, E. M., V. G. Wong, and E. J. Freireich: Inhibition of the local inflammatory response in man by antimetabolites. Blood 27, 38 (1966).
Johnson, H. A., and V. P. Bond: A method of labeling tissues with tritiated thymidine in vitro and its use in comparing rates of cellproliferation in duct epithelium, fibroadenoma and carcinoma of human heart. Cancer (Philad.) 14, 639 (1961).
Morgan, J. F., H. J. Morton, and R. C. Parker: Nutrition of animal cells in tissue culture. Proc. Soc. exp. Biol. (N. Y.) 73, 1 (1950).
Nowell, P. C.: Inhibition of human leucocyte mitosis by prednisolone in vitro. Cancer Res. 21, 1518 (1961).
Page, A. R., R. M. Condie, and R. A. Good: Effect of 6-mercaptopurine on inflammation. Amer. J. Path. 40, 519 (1962).
Rebuck, J. W., and J. H. Crowley: A method of studying leukocytic functions. Ann. N. Y. Acad. Sci. 59, 757 (1955).
Schwartz, R., and J. Andre: The chemical suppression of immunity. In: Grabar, P., and P. Miescher: Mechanism of cell and tissue damage produced by immune reactions, p. 385. II. Internat. Sympos. Immunpath., Basel (Schweiz)-Stuttgart 1965.
Theml, H., F. Trepel, J. Rastetter u. H. Begemann: DNS- und RNS-Synthese in benignen und malignen Lymphomen. Klin. Wschr. 45, 609 (1967).
Trepel, F., P. Schick u. H. Begemann: Morphologische und funktionelle Veränderungen im Blutzellsystem des Meerschweinchens mit zytostatischen Substanzen, Prednisolon und Phenylbutazon. III. Veränderungen einer immunologischen und einer unspezifischen Entzündungsreaktion. Z. ges. exp. Med. 149, 25 (1968).
Trepel, F., G. Stockhusen, J. Rastetter u. H. Begemann: Zytostatikawirkung auf die Nukleinsäureund Proteinsynthese von benignen und malignen Lymphomen. Chemotherapia (Basel) 12, 182 (1967).
Trowell, O. A.: The action of cortisone on lymphocytes in vitro. J. Physiol. (Lond.) 119, 274 (1953).
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Begemann, H. (1969). The Effect of Cytostatic Agents on Nucleic Acid and Protein Synthesis and on Immunological and Non-Immunological Inflammation. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_10
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DOI: https://doi.org/10.1007/978-3-642-49733-9_10
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