Abstract
The precursors to melanoma are generally considered to be related to nevi of different types. Here we emphasize the dysplastic nevus, the congenital nevus, and lentigo maligna as specific lesions. The dysplastic nevus is discussed not only as a formal precursor but also as a marker of cutaneous melanoma. The clinical and histologic characteristics are outlined, as well as evidence of progression in dysplastic nevi. The congenital nevus is briefly reviewed and emphasis is placed upon clues to malignant degeneration. The concept of lentigo maligna as a precursor as distinct from an in situ phase is detailed.
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References
Crowson AN, Magro CM, Mihm MC Jr (2001) The melanocytic proliferations: a comprehensive textbook of pigmented lesions. Wiley-Liss, New York, pp 209–223, 225–280, 282–447, 162–175.
Lynch HT, Frichot B, Lynch JF (1978) Familial atypical multi-mole melanoma syndroms J Med Genet 15:352–356.
Clark WB, Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ (1978) Origin of familial malignant melanomas from heritable melanocytic lesions. “The B-K mole syndrome”. Arch Dermatol 114:732–738.
Shea CR, Vollmer RT, Prieto VG (1999) Correlating architectural disorder and cytologic atypia in Clark (dysplastic) melanocytic nevi. Hum Pathol 30:500–505.
Nordlund JJ, Kirkwood J, Forget BM, et al. (1985) Demographic study of clinically atypical (dysplastic) nevi in patients with melanoma and comparison subjects. Cancer Res 45:1855–1861.
Grob JJ, Andrac L, Romano MH, et al. (1988) Dysplastic naevus in non-familial melanoma. A clinicopathological study of 101 cases. Br J Dermatol 118:745–752.
Cannon-Albright LA, Meyer LJ, Lewis CM, et al. (1994) Penetrance and expressivity of the chromosome 9p melanoma susceptibility locus (MLM). Cancer Res 54:6041–6044.
Greene MH, Clark WH, Tucker MA, Kraemer KH, Elder DE, Fraser MC (1985) High risk of malignant melanoma in melanoma-prone families with dysplastic nevi. Ann Intern Med 102:458–465.
Park WS, Vortmeyer AO, Pack S, et al. (1998) Allelic deletion at chromosome 9p21(pl6) and 17pl3(p53) in microdissected sporadic dysplastic nevus. Hum Pathol 29:127–130.
Birindelli S, Tragni G, Bartoli C, et al. (2000) Detection of microsatellite alterations in the spectrum of melanocytic nevi in patients with or without individual or family history of melanoma. Int J Cancer 86:255–261.
Vasen HF, Gruis NA, Frants RR, van der Velden PA, Hille ET, Bergman W (2000) Risk of developing pancreatic cancer in families associated with a specific 19 bp deletion of pl6 (pl6-Leiden). Int J Cancer 87:809–811.
Mcintosh LM, Summers R, Jackson M, et al. (2001) Towards non-invasive screening of skin lesions by near-infrared spectroscopy. J Invest Dermatol 116:175–181.
Clemente C, Cochran A J, Elder DE, et al. (1991) Histopathologic diagnosis of dysplastic nevi: concordance among pathologists convened by the World Health Organization Melanoma Programme. Hum Pathol 22:313–319.
Toussaint S, Kamino H (1999) Dysplastic changes in different types of melanocytic nevi. A unifying concept J Cutan Pathol 26:84–90.
Murphy G, Mihm MC Jr (1999) Recognition and evaluation of cytological dysplasia in acquired melanocytic nevi. Hum Pathol 30:506–512.
Hastrup N, Clemmensen OJ, Spaun E, Sondergaard K (1994) Dysplastic naevus: histopathologic criteria and their inter-observer reproducibility. Histopathology 24:503–509.
Clark WH, Mihm MC (1969) Lentigo maligna and lentigo maligna melanoma. Am J Pathol 55:39–54.
Tannous ZS, Lerner LH, Duncan LM, Mihm MC Jr, Flotte TJ (2000) Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type. Hum Pathol 31:705–708.
Weinstock MA, Sober AJ (1987) The risk of progression of lentigo maligna to lentigo maligna melanoma. Br J Dermatol 116:303–310.
Grammatico P, Modesti A, Steindl K, et al. (1992) Lentigo maligna: cytogenetic, ultra- structural, and phenotypic characterization of a primary cell culture. Cancer Genet Cy- togenet 60:141–146.
Koh HK, Michalik E, Sober AJ, et al. (1984) Lentigo maligna melanoma has no better prognosis than other types of melanoma. J Clin Oncol 2:994–1001.
Cohen LM (1995) Lentigo maligna and lentigo maligna melanoma. J Am Acad Dermatol 33:923–936.
Bittencourt FV, Marghoob AA, Kopf AW, Koenig KL, Bart RS (2000) Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis. Pediatrics 106:736–741.
Swerdlow AJ, English JS, Qiao Z (1995) The risk of melanoma in patients with congenital nevi: a cohort study. J Am Acad Dermatol 32:595–599.
Lowes MA, Norris D, Whiteld M (2000) Benign melanocytic proliferative nodule within a congenital naevus. Austr J Dermatol 41:109–111.
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Crowson, A.N., Magro, C.M., Sanchez-Carpintero, I., Mihm, M.C. (2002). The Precursors of Malignant Melanoma. In: Dummer, R., Nestle, F.O., Burg, G. (eds) Cancers of the Skin. Recent Results in Cancer Research, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59410-6_11
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DOI: https://doi.org/10.1007/978-3-642-59410-6_11
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