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Overview of the Mucosal Immune System

  • Conference paper
New Strategies for Oral Immunization

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 146))

Abstract

The existence of a protective local immune system that seemed to function independently of systemic immunity, was initially proposed by Besredka (1919); he observed that rabbits, after oral immunization with killed Shiga bacillus, were protected against fatal dysentery irrespective of the serum antibody titer. Davies (1922) obtained evidence in soldiers stationed around Jerusalem, to suggest for the first time the presence of local immunity in humans; his observations indicated that bacterial agglutinins could appear in dysentery stools several days earlier than in the blood. The molecular basis for local immunity was established when Tomasi et al. (1965) confirmed that external secretions contained a unique immunoglobulin (Ig) subsequently called secretory IgA (SIgA).

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Author information

Authors and Affiliations

  1. Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, Rikshopitalet, N-0027, Oslo 1, Norway

    P. Brandtzaeg

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  1. P. Brandtzaeg
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Editors and Affiliations

  1. Medicine and Oral Biology, USA

    Jiri Mestecky M.D. (Professor of Microbiology) (Professor of Microbiology)

  2. Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35 294, Birmingham, Alabama, USA

    Jerry R. McGhee Ph. D. (Professor of Microbiology) (Professor of Microbiology)

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© 1989 Springer-Verlag Berlin · Heidelberg

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Brandtzaeg, P. (1989). Overview of the Mucosal Immune System. In: Mestecky, J., McGhee, J.R. (eds) New Strategies for Oral Immunization. Current Topics in Microbiology and Immunology, vol 146. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74529-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-74529-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74531-7

  • Online ISBN: 978-3-642-74529-4

  • eBook Packages: Springer Book Archive

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