Abstract
Due to an inherent complementality which exists between the two base pairs, adenine-thymine and guanine-cytosine, DNA is endowed with the unique property of being able to make an exact replica of itself before each cell division. Yet, if the mechanism of DNA replication were perfect and there was no room for mistakes, the creation of divergent living creatures from a common ancestor could not have happened.
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References
Fitch, W.M.: An improved method of testing for evolutional homology. T. Mol. Biol. 16 9–16(1966).
Garen, A.: Sense and nonsense in the genetic code. Science 160, 149–159 (1968).
Kilmartin, J.V., Clegg, J.B.: Amino-acid replacements in horse hemoglobin. Nature 213, 269–271 (1967).
Terzaghi, E., Okada, Y., Streisinger, G., Emrich, J., Inouye, M., Tsugita, A.: Change of a sequence of amino acids in phage T4 lysozyme by acridine induced mutations. Proc. Natl. Acad. Sci. US 56, 500–507 (1966).
Whitfield, H.J., Martin, R.G., Ames, B.N.: Classification of aminotransferase (C gene) mutants in the histidine operon. J. Mol. Biol. 21, 335–355 (1966).
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Ohno, S. (1970). Mutation as a Change in the Base Sequence of a DNA Cistron. In: Evolution by Gene Duplication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86659-3_5
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DOI: https://doi.org/10.1007/978-3-642-86659-3_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-86661-6
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