Abstract
Only the amino acid sequence of a polypeptide chain defines its function. A polypeptide chain having a certain amino acid sequence serves as a subunit of immunoglobulin, while another polypeptide chain having a different amino acid sequence functions as a subunit of an enzyme, such as lactate dehydrogenase. It then follows that a change in the amino acid sequence of a polypeptide chain can deprive that polypeptide chain from the performance of its assigned function.
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References
Gerald, P.S., Scott, E.M.: The hereditary methemoglobinemias. In: The metabolic basis of inherited disease, 2nd ed., pp. 1090–1099.
Stanbury, J.B., Wyngaarden, J.B., Frederickson, D.S. Eds. New York: McGraw-Hill Book Co. 1966.
Isselbacher, K.J., Anderson, E.P., Kurahashi, K., Kalckar, H.M.: Congenital galactosemia, a single enzymatic block in galactose metabolism. Science 123, 635–636 (1956).
Jervis, G.A.: Phenylpyruvic oligophrenia: Deficiency of phenylalanine oxydizing system. Proc. Soc. Exptl. Biol. Med. 82, 514 (1953).
Kaplan, N.O.: Evolution of dehydrogenases. In: Evolving genes and proteins, Bryson, V. Vogel, J.H., Eds. New York: Academic Press 1965.
Kauffman, D.L.: The disulphide bridges of trypsin. J. Mol. Biol. 12, 929–932 (1965).
Keil, B., PrusÃk, Z., Å orm, F.: Disulphide bridges and a suggested structure of chymotrypsinogen. Biochim. et Biophys. Acta 78, 559–561 (1963).
Kendrew, J. C, Dickerson, R.E., Strandberg, B.E., Hart, R.G., Davies, D.R., Phillips, D. C, Shore, U.C.: Structure of myoglobin: A three-dimensional fourier synthesis at 2 Å resolution obtained by X-ray analysis. Nature 185, 422–427 (1960).
Mathai, C.K., Pilson, M.E.Q., Beutler, E.: Galactose metabolism in the sea lion. Proc. Soc. Exptl. Biol. Med. 123, 4–5 (1966).
Perutz, M.F., Rossmann, M.B., Cullis, A.F., Muirhead, H., Will, G., North, A.C.T.: Structure of hemoglobin: A three dimensional fourier synthesis at 5.5 Å resolution, obtained by X-ray analysis. Nature 185, 416–422 (1960).
Simpson, G.G.: Organisms and molecules in evolution. Science 146, 1535–1538 (1964).
Searle, A.G.: Comparative genetics of coat colour in mammals. London: Logos Press, Ltd. 1968.
Wolfe, H.G., Coleman, D.L.: Pigmentation, In: Biology of the laboratory mouse, 2nd ed. Green, E.L., Ed. New York: McGraw-Hill 1966.
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Ohno, S. (1970). Forbidden Mutations. In: Evolution by Gene Duplication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86659-3_6
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DOI: https://doi.org/10.1007/978-3-642-86659-3_6
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