Skip to main content
SpringerLink
Log in

The Interaction Between Dendritic Cells and Herpes Simplex Virus-1

  • Chapter
Dendritic Cells and Virus Infection

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 276))

Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells, because they are also able to induce native T cells. Thus they are crucial in the induction of antiviral immune responses. Several viral immune escape mechanisms have been described; here we concentrate on the interaction between DCs and herpes simplex virus type 1 (HSV-1). DCs can be infected by HSV-1; however, only immature DCs generate infectious viral particles, whereas mature DCs do not support virus production and only immediate-early and early viral transcripts are generated. To induce potent immune responses DCs must mature. Interestingly, HSV-1 interferes with this maturation process, thus inhibiting antiviral T cell stimulation. Furthermore, HSV-1 strongly interferes with DC-mediated T cell proliferation. A striking finding was the complete degradation of CD83, the best-known marker for mature DC, after HSV-1 infection in lysosomal compartments. This CD83 degradation coincided with a clearly reduced T cell stimulation representing an additional new escape strategy. The functional role and the importance of CD83 are discussed in detail.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arrode G, Boccaccio C, Abastado JP, Davriinche C: Cross-presentation of human cytomegalovirus pp65 (UL83) to CD8+ T cells is regulated by virus-induced, soluble-mediator-dependent maturation of dendritic cells. J. Virol. 2002; 76: 142

    Article  PubMed  CAS  Google Scholar 

  • Aprhys C, O’Neill E, Kelly TJ, Hayward GS (1989) Overlapping octamer and TAATGARAT motifs in the VF65-response elements in herpes simplex virus immediate-early promoters represent independent binding sites for cellular nuclear factor III. J. Virol. 63: 2798–2812

    PubMed  CAS  Google Scholar 

  • Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. (2000) Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767–811

    Google Scholar 

  • Bevec D, Jaksche H, Oft M, WShl T, Himmelspach M, Pacher A, Schebsta M, Koettnitz K, Dobrovnik M, Csonga R, Lottspeich F, Hauber J. (1996) Inhibition of HIV-1 replication in lymphocytes by mutants of the REV cofactor eIF-5A. Science. 271: 1858

    Article  PubMed  CAS  Google Scholar 

  • Boussiotis VA, Gribben JG, Freeman GJ, Naddler LM. (1994) Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr. Opin. Immunol. 6: 797

    Google Scholar 

  • Carrozza MJ and DeLuca NA (1996) Interaction of the viral activator protein ICP4 with TFIID through TAF250. Mol. Cell. Biol. 295: 1103–1112

    Google Scholar 

  • Carter KL, Ward PL, Roizman B (1996) Characterization of the products of the UL43 gene of herpes simplex virus 1: Potential implications for regulation of gene expression by antisense transcription. J. Virol. 70: 7663–7668

    Google Scholar 

  • Challberg M (1996) Herpesvirus DNA replication. DNA Replication in Eukaryotic Cells. DePamphilis ML (Ed), Cold Spring Harbor Laboratory Press, NY, USA: 721–750

    Google Scholar 

  • Cocchi F, Menotti L, Mirandola P, Lopez M, Campadelli-Fiume G. (1998) The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. J Virol. 72 (12): 9992–10002

    PubMed  CAS  Google Scholar 

  • Elfgang C, Rosorius O, Hofer L, Jaksche H, Hauber J, Bevec D. (1999) Evidence for specific nucleocytoplasmic transport pathways used by leucin-rich nuclear export signals. Proc. Natl. Acad. Sci. USA 96: 6229

    Google Scholar 

  • Engelmayer J, Larsson M, Subklewe M et al. (1999) Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion. J. Immunol. 163: 6762–6768

    PubMed  CAS  Google Scholar 

  • Everett RD (2000) ICP0 induces the accumulation of colocalizing conjugated ubiqui-tin. J. Virol. 74: 9994–10005

    Article  PubMed  CAS  Google Scholar 

  • Everly DN and Read GS (1999) Site-directed mutagenesis of the virion host shutoff gene (UL41) of Herpes Simplex virus (HSV): Analysis of Functional Differences between HSV Type 1 (HSV-1) and HSV-2 alleles. J. Virol. 73: 9117–9129

    PubMed  CAS  Google Scholar 

  • Fujimoto Y, Tu L, Miller AS, Bock C, Fujimoto M, Doyle C, Steeber DA, Tedder TF. (2002) CD83 Expression influences CD4+ T cell development in the thymus. Cell 108: 755

    Article  PubMed  CAS  Google Scholar 

  • Geiss BJ, Smith TJ, Leib DA, Morrison LA (2000) Disruption of virion host shutoff activity improves the immunogenicity and protective capacity of a replication-incompetent Herpes Simplex Virus Type 1 vaccine strain. J.Virol. 74: 11137–11144

    Article  PubMed  CAS  Google Scholar 

  • Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG (1998) Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and polio-virus receptor. Science 280: 1618–1620

    Article  PubMed  CAS  Google Scholar 

  • Hammerschmidt W and Mankertz J (1991) Herpesviral DNA replication: Between the known and the unknown. Seminars Virology 2: 257–269

    CAS  Google Scholar 

  • Hammerschmidt W (2000) Herpesvirus vectors come of age. Curr. Opin.Mol. Ther. 2 (5): 532–539

    PubMed  CAS  Google Scholar 

  • Hardwicke MA, Sandri-Goldin RM (1994) The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection. J. Virol. 68: 4797–4810

    PubMed  CAS  Google Scholar 

  • Hardy WR, Sandri-Goldin RM (1994) Herpes simplex virus inhibits host cell splicing, and the regulatory protein ICP27 is required for this effect. J. Virol. 68: 7790– 7799

    Google Scholar 

  • Herold BC, Visalli RJ, Susmarski N, Brandt CR, Spear PG. (1994) Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B. J Gen Virol. 75 (Pt 6): 1211–22

    Article  PubMed  CAS  Google Scholar 

  • Hock BD, Kato M, McKenzie JL, Hart DNJ. (2001) A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera. Int. Immunol. 13: 959

    Google Scholar 

  • Howard MK, Kershaw T, Gibb B, Storey N, MacLean AR, Zeng BY, Tel BC, Jenner P, Brown SM, Woolf CJ, Anderson PN, Coffin RS, Latchman DS (1998) High efficient gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5. Gene Ther. 5 (8): 1137–1147

    Article  PubMed  CAS  Google Scholar 

  • Jenne L, Schuler G, Steinkasserer A. (2001) Viral vectors for dendritic cell-based immunotherapy. Trends Immunol. 22 (2): 102–107

    Article  PubMed  CAS  Google Scholar 

  • Jonuleit H, Schmitt E, Steinbrink K, Enk AH. (2001) Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol. 22 (7): 394–400

    Article  PubMed  CAS  Google Scholar 

  • Kang HA, Hershey JWB. (1994) Effect of initiation factor eIF-5A depletion on protein synthesis and proliferation of Saccharomyces cervisiae. J. Biol. Chem. 269: 3934

    Google Scholar 

  • Kruse M, Rosorius M, Krätzer F, Bevec D, Kuhnt C, Steinkasserer A, Schuler G, Hauber J (2000a) Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA. J. Ex. Med. 191 (9): 1581–1590

    Article  CAS  Google Scholar 

  • Kruse M, Rosorius O, Krätzer F, Bevec D, Kuhnt C, Steinkasserer A, Sxhuler G, Hauber J. (2000b) Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA. J. Exp. Med. 191: 1581

    Google Scholar 

  • Lam Q, Smibert CA, Koop KE, Lavery C, Capone JP, Weinheimer SP, Smiley JR (1996) Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function. EMBO J. 15: 2575–2581

    PubMed  CAS  Google Scholar 

  • Lechmann M, Krooshoop DJEB, Dudziak D, Kremmer E, Kuhnt C, Figdor CG, Schuler G, Steinkasserer A. (2001) The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells. J. Exp. Med. 194: 1813

    Google Scholar 

  • Lechmann M, Kremmer E, Sticht H, Steinkasserer A. (2002a) Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies. Prot. Exp. Purif. 2002; 24: 445

    Article  Google Scholar 

  • Lechmann M, Berchtold S, Hauber J, Steinkasserer A. (2002b) CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 23 (6): 273–275

    Article  PubMed  CAS  Google Scholar 

  • Lopez M, Cocchi F, Menotti L, Avitabile E, Dubreuil P, Campadelli-Fiume G (2000) Nectin2a (PRR2a or HveB) and Nectin2d are low-efficiency mediators for entry of Herpes Simplex virus mutants carrying the Leu25Pro Substitution in Glycoprotein D. J. Virol. 74: 1267–1274

    Article  PubMed  CAS  Google Scholar 

  • Lu P, Safran HA, Smiley JR (2001) The vhs1 mutant form of Herpes Simplex Virus virion host shutoff protein retains significant internal ribosome entry site-directed RNA cleavage activity. J. Virol. 75: 1072–1076

    Article  PubMed  CAS  Google Scholar 

  • Mikloska Z, Bosnjak L, Cunningham AL (2001) Immature Monocyte-derived dendritic cells are productively infected with Herpes Simplex Virus Type 1. J. Virol. 75: 5958–5964

    Article  PubMed  CAS  Google Scholar 

  • Montgomery RI, Warner MS, Lum BJ, Spear PG (1996) Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87: 427–436

    Article  PubMed  CAS  Google Scholar 

  • Mossman KL, Sherburne R, Lavery C, Duncan J, Smiley JR (2000) Evidence that Herpes Simplex Virus VP16 is required for viral egress downstream of the initial envelopment event. J. Virol. 74: 6287–6299

    Article  PubMed  CAS  Google Scholar 

  • Mossman KL and Smiley JR (1999) Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex VP16 renders expression of the immediate-early genes almost entirely dependent on ICP0. J. Virol. 73: 9726–9733

    PubMed  CAS  Google Scholar 

  • Mullen MA, Gerstberger S, Ciufo DM, Mosca JD, Hayward GS (1995) Evaluation of colocalization interactions between the IE110, IE175, and IE63 transactivator proteins of Herpes Simplex virus within subcellular punctate structures. J. Virol. 69: 476–491

    PubMed  CAS  Google Scholar 

  • Novotny MJ, Parish ML, Spear PG (1996) Variability of Herpes Simplex Virus 1 gL and anti-gl antibodies that inhibit cell fusion but not viral infectivity. Virology 221: 1–13

    Article  PubMed  CAS  Google Scholar 

  • Oroskar AA and Read GS (1989) Control of mRNA stability by the virion host shutoff function of herpes simplex virus. J. Virol. 63: 1897–1906

    PubMed  CAS  Google Scholar 

  • Palmer JA, Branston RH, Lilley CE, Robinson MJ, Groutsi F, Smith J, Latchman DS, Coffin RS (2000) Development and optimization of Herpes Simplex Virus vectors for multiple long-term gene delivery to the peripheral nervous system. J. Virol. 74: 5604–5618

    Article  PubMed  CAS  Google Scholar 

  • Park MH, Wolff EC, Folk JE. (1993a) Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation. Biofactors 1993; 4: 95

    Google Scholar 

  • Park MH, Wolff EC, Folk JE. (1993b) Is hyposine essential for eukaryotic cell proliferation? Trends Biochem. Sci. 18: 475

    CAS  Google Scholar 

  • Parkinson J and Everett RD (2001) Alphaherpesvirus proteins related to Herpes Simplex Virus Type 1 ICP0 induce the formation of colocalizing, conjugated Ubiqui-tin. J. Virol. 75: 5357–5362

    Article  PubMed  CAS  Google Scholar 

  • Phelan A and Clements JB (1998) Post-transcriptional regulation in herpes simplex virus. Semin. Virol. 8: 309–318

    Article  CAS  Google Scholar 

  • Preston CM and Nicholl MJ (1997) Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis. J. Virol. 71: 7807–7813

    PubMed  CAS  Google Scholar 

  • Rosorius O, Reichart B, Krätzer F, Heger P, Dabauvalle MC, Hauber J. (1999) Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1. J. Cell. Sci. 112: 2369

    Google Scholar 

  • Salio M, Cella M, Suter M, Lanzavecchia A (1999) Inhibition of dendritic cell maturation by herpes simplex virus. Eur. J. Immunol. 29: 3245–3253

    Google Scholar 

  • Scholler N, Hayden-Ledbetter M, Dahlin A, Hellström I, Hellström K-E, Ledbetter JA. (2002) CD83 regulates the development of cellular immunity. J. Immunol. 168: 2599

    PubMed  CAS  Google Scholar 

  • Sears AE, Halliburton IW, Meignier B, Silver S, Roizman B (1985) Herpes simplex virus 1 mutant deleted in the a22gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice. J. Virol. 55: 338–346

    PubMed  CAS  Google Scholar 

  • Slomka MJ, Emery L, Munday PE, Moulsdale M, Brown DW (1998) A comparison of PCR with virus isolation and direct antigen detection for diagnosis and typing of genital herpes. J. Med. Virol. 55: 177–183

    Google Scholar 

  • Smibert CA, Popova B, Xiao P, Capone JP, Smiley JR (1994) Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs. J. Virol. 68: 2339– 2346

    Google Scholar 

  • Stevens JG, Wagner EK, Devi-Rao GB, Cook ML, Feldman LT (1987) RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235: 1056–1059

    Article  PubMed  CAS  Google Scholar 

  • Spear PG, Eisenberg RJ, Cohen GH (2000) Three classes of cell surface receptors for alphaherpesvirus entry. Virology 275: 1–8

    Article  PubMed  CAS  Google Scholar 

  • Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9: 271–296

    Article  PubMed  CAS  Google Scholar 

  • Strelow LI and Leib DA (1995) Role of the Virion Host Shutoff (vhs) of Herpes Simplex Virus Type 1 in Latency and Pathogenesis. J. Virol. 69: 6779–6786

    PubMed  CAS  Google Scholar 

  • Ward PL, Barker E, Roizman B (1996) A novel herpes simplex virus 1 gene, UL43.5, maps antisense to the UL43 gene and encodes a protein which colocalizes in nuclear structures with capsid proteins. J. Virol. 70: 2684–2690

    PubMed  CAS  Google Scholar 

  • Warner MS, Geraghty RJ, Martinez WM, Montgomery RI, Whitbeck JC, Xu R, Eisenberg RJ, Cohen GH, Spear PG (1998) A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology 246: 179–189

    Article  PubMed  CAS  Google Scholar 

  • Whitley RJ and Gnann JW Jr. (1992) Acyclovir: a decade later. N. Engl. J. Med. 327: 782–789. [Errata, (1993) 328: 671, (1997) 337:1703]

    Google Scholar 

  • Whitley RJ (1996) Herpes simplex viruses. B. Fields and D. Knipe, ed. Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, PA

    Google Scholar 

  • Zhou LJ and Tedder TF (1995) Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154: 3821– 3835

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, University of Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany

    D. Kobelt, M. Lechmann & A. Steinkasserer

Authors
  1. D. Kobelt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Lechmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Steinkasserer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dermatologische Klinik, Universität Erlangen, Hartmannstr. 14, 91052, Erlangen, Germany

    Alexander Steinkasserer

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kobelt, D., Lechmann, M., Steinkasserer, A. (2003). The Interaction Between Dendritic Cells and Herpes Simplex Virus-1. In: Steinkasserer, A. (eds) Dendritic Cells and Virus Infection. Current Topics in Microbiology and Immunology, vol 276. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06508-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-06508-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07926-9

  • Online ISBN: 978-3-662-06508-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation