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Beneficial Effects of Honey Flavonoids in Nonalcoholic Fatty Liver Disease: An Update

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Therapeutic Applications of Honey and its Phytochemicals

Abstract

Chemically, flavonoids are phenolic compounds. These are natural substances that have several pharmacological properties like anti-oxidative, anti-inflammatory, antimutagenic, and anti-carcinogenic and modulate key cellular enzyme function. Potent enzyme inhibitors for several enzymes like xanthine oxidase (XO), cyclooxygenase (COX), lipoxygenase, and phosphoinositide 3-kinase. Honey is a natural source of flavonoids. Non-alcoholic fatty liver disease (NAFLD) includes several diseases, ranging from steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. Flavonoids have been used for the treatment of NAFLD. Groups of pathways involved in the pathogenesis of NAFLD support the treatment. Flavonoids have positive effects on insulin resistance, lipid metabolism, inflammation, and oxidative stress that are prominent pathophysiological pathways in NAFLD.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Maulana Azad University, Jodhpur, Rajasthan, India

    Mohamad Taleuzzaman

  2. Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

    Rishabh Verma

  3. Faculty of Pharmacy, Department of Pharmacology, Maulana Azad University, Jodhpur, Rajasthan, India

    Chandra Kala

  4. Department of Pharmacology, IIMT College of Medical Sciences, IIMT University, Meerut, India

    Parul Sharma

  5. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

    Dipak Kumar Gupta

Authors
  1. Mohamad Taleuzzaman
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  2. Rishabh Verma
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  3. Chandra Kala
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  4. Parul Sharma
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  5. Dipak Kumar Gupta
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacy, King Saud University, Riyadh, Riyadh, Saudi Arabia

    Muneeb U. Rehman

  2. Department of Biochemistry, Govt. Medical College (GMC-Srinagar), Srinagar, Jammu and Kashmir, India

    Sabhiya Majid

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Taleuzzaman, M., Verma, R., Kala, C., Sharma, P., Gupta, D.K. (2020). Beneficial Effects of Honey Flavonoids in Nonalcoholic Fatty Liver Disease: An Update. In: Rehman, M.U., Majid, S. (eds) Therapeutic Applications of Honey and its Phytochemicals . Springer, Singapore. https://doi.org/10.1007/978-981-15-7305-7_17

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