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Containers Based Drug Delivery for Neuroscience

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Micro- and Nano-containers for Smart Applications

Part of the book series: Composites Science and Technology ((CST))

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Abstract

Drug development for neuroscience or targeting the brain is challenging and considered a complex research area in pharmaceutical sciences. To act upon these drugs should be able to reach their site of action. However, these sites are protected from all external entities by several barriers. The blood–brain barrier (BBB) prevents the entry of many drugs, including antibiotics, neuropeptides Etc. The complexity of brain disorders and the presence of BBB prevents the development of drugs. The past decade has seen a boom in the drug delivery methods for treatment in neuroscience. One reason for this is the alarming increase in the neurological diseases observed. The other reason is that a lot of information is now available about the CNS and a better understanding of the methods and the drug interaction through which efficient drug delivery can occur. Many strategies like colloidal drug carriers, cell-penetrating peptides, receptor and carrier-mediated transport need further research.

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Abbreviations

BBB:

Blood Brain Barrier

CNS:

Central Nervous System

DALY:

Years of Life Lost (YLL)

YLD:

Years Lived with Disability

CMT:

Carrier Mediated Transport

RMT:

Receptor Mediated Transport

CDDS:

Chemical Drug Delivery System

CSF:

Cerebrospinal Fluid

CPP:

Cell Penetrating Peptides

FUS:

focused ultrasound

Tf:

iron binding protein transferrin

TfR:

Tf receptor

PEG-PLA:

Poly ethylene glycol-poly lactic acid

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Authors and Affiliations

  1. Centre for Neuroscience, Cochin University of Science and Technology (CUSAT), Kochi, 682022, Kerala, India

    Dania Alphonse Jose,  Krishnapriya & P. S. Baby Chakrapani

  2. Department of Biotechnology, Cochin University of Science and Technology (CUSAT), Kochi, 682022, Kerala, India

    Dania Alphonse Jose,  Krishnapriya & P. S. Baby Chakrapani

  3. Inter University Centre for Nanomaterials and Devices (IUCND), Cochin University of Science and Technology (CUSAT), Kochi, 682022, Kerala, India

    P. S. Baby Chakrapani

  4. Centre of Excellence in Advanced Materials, Cochin University of Science and Technology (CUSAT), Kochi, 682022, Kerala, India

    P. S. Baby Chakrapani

Authors
  1. Dania Alphonse Jose
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  2. Krishnapriya
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  3. P. S. Baby Chakrapani
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Corresponding author

Correspondence to P. S. Baby Chakrapani .

Editor information

Editors and Affiliations

  1. Department of Science, Alliance University, Faculty of Science & Technology, Bengaluru, Karnataka, India

    Jyotishkumar Parameswaranpillai

  2. Swinburne University of Technology, Hawthorn, VIC, Australia

    Nisa V. Salim

  3. King Mongkut's University of Technology, Bangkok, Thailand

    Harikrishnan Pulikkalparambil

  4. King Mongkut's University of Technology, Bangkok, Thailand

    Sanjay Mavinkere Rangappa

  5. King Mongkut's University of Technology, Bangkok, Thailand

    Ing. habil Suchart Siengchin

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Jose, D.A., Krishnapriya, Baby Chakrapani, P.S. (2022). Containers Based Drug Delivery for Neuroscience. In: Parameswaranpillai, J., V. Salim, N., Pulikkalparambil, H., Mavinkere Rangappa, S., Suchart Siengchin, I.h. (eds) Micro- and Nano-containers for Smart Applications. Composites Science and Technology . Springer, Singapore. https://doi.org/10.1007/978-981-16-8146-2_14

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