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Three Methods for the Solution Phase Synthesis of Cyclic Peptides

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Peptide Macrocycles

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2371))

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Abstract

Cyclic peptides, which often exhibit interesting biological properties, can be obtained by macrolactamization of adequately protected linear peptide chains. Because of the remarkable biological properties, methods for the efficient cyclization of peptides are of high interest. We herein describe three different protocols for the cyclization of peptides and depsipeptides via amide bond formation. These methods can, in principal, be applied to any linear peptide chain.

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Acknowledgments

This work was supported by Saarland University.

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Authors and Affiliations

  1. Organic Chemistry, Saarland University, Saarbrücken, Germany

    Angelika Ullrich, Lukas Junk & Uli Kazmaier

Authors
  1. Angelika Ullrich
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  2. Lukas Junk
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  3. Uli Kazmaier
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Corresponding author

Correspondence to Angelika Ullrich .

Editor information

Editors and Affiliations

  1. DEVCOM Army Research Lab, Adelphi, MD, USA

    Matthew B. Coppock

  2. DEVCOM Army Research Lab, Adelphi, MD, USA

    Alexander J. Winton

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Ullrich, A., Junk, L., Kazmaier, U. (2022). Three Methods for the Solution Phase Synthesis of Cyclic Peptides. In: Coppock, M.B., Winton, A.J. (eds) Peptide Macrocycles. Methods in Molecular Biology, vol 2371. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1689-5_4

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  • DOI: https://doi.org/10.1007/978-1-0716-1689-5_4

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1688-8

  • Online ISBN: 978-1-0716-1689-5

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