Abstract
Joseph Leighton developed sponge-matrix histoculture in the early 1950s and is the father of true 3D cell and tissue culture. Dr. Leighton demonstrated that sponge-matrix histoculture could replicate in vivo-like tissue structure and function by allowing cells to take their natural shape.
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References
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Hoffman, R.M. (2018). In Memoriam: Joseph Leighton, 1921–1999—Father of 3-Dimensional Tissue Culture. In: Hoffman, R. (eds) 3D Sponge-Matrix Histoculture. Methods in Molecular Biology, vol 1760. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7745-1_1
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DOI: https://doi.org/10.1007/978-1-4939-7745-1_1
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