Abstract
Purpose
This study focuses on distal radius fractures that require surgical treatment. Patients with diabetes mellitus (DM) are at increased risk of bone fracture despite normal areal bone mineral density. The aim of this study is to identify the impact of DM on perioperative complications for patients undergoing operative treatment of distal radius fracture.
Methods
A retrospective cohort study was conducted using data collected through the National Surgical Quality Improvement Program database. All patients who underwent operative treatments for distal radius fractures from 2007 through 2018 were identified. Data collected include demographic information, comorbidities, and complications occurring within 30 days of initial surgical intervention. The incidence of adverse events following surgery was evaluated with univariate and multivariate analyses where appropriate.
Results
Patients with DM were found to have a low rate of complications postsurgical repair of distal radius fractures. Preoperative comorbidity analysis showed that the diabetic group had significantly higher rates of chronic obstructive pulmonary disease, hypertension, congestive heart failure, renal failure, steroid use, bleeding disorders, dyspnea, and poorer functional status. Diabetes was found to be an independent predictor for unplanned intubation, sepsis, and septic shock. Diabetes was not found to be an independent predictor of other postoperative complications.
Conclusion
Complications after surgical repair of distal radius fracture are low except when it comes to reintubation, sepsis, and septic shock. While the risks of independent complications remain relatively low, diabetes remains an important factor to consider when selecting surgical candidates and to ensure appropriate pre-operative risk assessment.
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References
Harness NG, Funahashi T, Dell R, Adams AL, Burchette R, Chen X, Greene D (2012) Distal radius fracture risk reduction with a comprehensive osteoporosis management program. J Hand Surg Am 37:1543–1549. https://doi.org/10.1016/j.jhsa.2012.04.033
Ju JH, Jin GZ, Li GX, Hu HY, Hou RX (2015) Comparison of treatment outcomes between nonsurgical and surgical treatment of distal radius fracture in elderly: a systematic review and meta-analysis. Langenbecks Arch Surg 400:767–779. https://doi.org/10.1007/s00423-015-1324-9
MacIntyre NJ, Dewan N (2016) Epidemiology of distal radius fractures and factors predicting risk and prognosis. J Hand Ther 29:136–145. https://doi.org/10.1016/j.jht.2016.03.003
Pang EQ, Truntzer J, Baker L, Harris AHS, Gardner MJ, Kamal RN (2018) Cost minimization analysis of the treatment of distal radial fractures in the elderly. Bone Joint J 100:205–211. https://doi.org/10.1302/0301-620X.100B2.BJJ-2017-0358.R1
Fan W (2017) Epidemiology in diabetes mellitus and cardiovascular disease. CardiovascEndocrinol 6:8–16. https://doi.org/10.1097/XCE.0000000000000116
Hoogwerf BJ (2001) Postoperative management of the diabetic patient. Med Clin North Am 85:1213–1228. https://doi.org/10.1016/s0025-7125(05)70373-4
Santos KA, Berto B, Sousa AG, Costa FA (2016) Prognosis and complications of diabetic patients undergoing isolated coronary artery bypass surgery. Braz J CardiovascSurg 31:7–14. https://doi.org/10.5935/1678-9741.20160002
Ramachandran SK, Nafiu OO, Ghaferi A, Tremper KK, Shanks A, Kheterpal S (2011) Independent predictors and outcomes of unanticipated early postoperative tracheal intubation after nonemergent, noncardiac surgery. Anesthesiology 115:44–53. https://doi.org/10.1097/ALN.0b013e31821cf6de
McKeen DM, George RB, O’Connell CM, Allen VM, Yazer M, Wilson M, Phu TC (2011) Difficult and failed intubation: incident rates and maternal, obstetrical, and anesthetic predictors. Can J Anaesth 58:514–524. https://doi.org/10.1007/s12630-011-9491-9
Evans HL, Warner K, Bulger EM, Sharar SR, Maier RV, Cuschieri J (2011) Pre-hospital intubation factors and pneumonia in trauma patients. Surg Infect (Larchmt) 12(5):339–344. https://doi.org/10.1089/sur.2010.074
Osuchowski MF, Craciun FL, Schuller E, Sima C, Gyurko R, Remick DG (2010) Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response. Shock 34:369–376. https://doi.org/10.1097/SHK.0b013e3181dc40a8
Frydrych LM, Fattahi F, He K, Ward PA, Delano MJ (2017) Diabetes and sepsis: risk, recurrence, and ruination. Front Endocrinol 8:271. https://doi.org/10.3389/fendo.2017.00271
Schuetz P, Castro P, Shapiro NI (2011) Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care 34:771–778. https://doi.org/10.2337/dc10-1185
Koh GC, Peacock SJ, van der Poll T, Wiersinga WJ (2012) The impact of diabetes on the pathogenesis of sepsis. Eur J ClinMicrobiol Infect Dis 31:379–388. https://doi.org/10.1007/s10096-011-1337-4
Guzmán G, Martínez V, Yara JD, Mina MA, Solarte JS, Victoria AM, Fériz K (2020) Glycemic control and hypoglycemia in patients treated with insulin pump therapy: an observational study. J Diabetes Res 2020:1581726. https://doi.org/10.1155/2020/1581726
Pritchard JM, Giangregorio LM, Atkinson SA et al (2012) Association of larger holes in the trabecular bone at the distal radius in postmenopausal women with type 2 diabetes mellitus compared to controls. Arthritis Care Res 64:83–91. https://doi.org/10.1002/acr.20602
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Wei, C., Kapani, N., Quan, T. et al. Diabetes mellitus effect on rates of perioperative complications after operative treatment of distal radius fractures. Eur J Orthop Surg Traumatol 31, 1329–1334 (2021). https://doi.org/10.1007/s00590-021-02880-x
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DOI: https://doi.org/10.1007/s00590-021-02880-x