We performed a complex morphological study of biopsy samples of prostate gland from 30 men (mean age 46±11 years) with chronic abacterial prostatitis who were exposed unfavorable anthropogenic factors. The ultrastructural heterogeneity of smooth muscle cells was shown, among which cells with destructive changes in organelles predominated, solitary cells with signs of secretory function were revealed. Most endothelial cells in microvessels were characterized by low pinocytotic activity, destruction of organelles; focal hyperplastic ultrastructural changes were noted in some endotheliocytes. Along with fibroblasts, the stroma contained single mast cells; no inflammatory infiltration was revealed. The results of the study attested to complex mechanisms of remodeling of the prostate gland stroma in chronic abacterial prostatitis involving microvessels, smooth muscle cells, and probably mast cells, which determines the development of degenerative, destructive, and fibrotic processes.
Similar content being viewed by others
References
Budnik AF, Urusbambetov ACh, Bogatyreva OE. Morphology of man prostate stroma in postnatal ontogenesis. Morfol. Ved. 2011;(4):19-22. Russian.
Kogan MI, Matsionis AE, Belousov II, Povilaitite PE. Morphological evidence of the ischemic nature of the prostatic fibrosis in the classical chronic pelvic pain syndrome / IIIB chronic prostatitis. Urologiya. 2018;(3):12-19. Russian.
Neimark AI, Kiptilov AV, Lapii GA. Clinical and pathomorphological features of chronic prostatitis in chemical industry workers. Urologiya. 2015;(6):68-73. Russian.
Sedova AO. Effect of chemical and finely-divided air pollutants on spermatogenesis and sperm parameters. Andrologiya Genital. Khirurgiya. 2019;20(2):29-34. Russian.
Sivkov AV, Romikh VV, Zakharchenko AV. Chronic prostatitis IIIB/chronic pelvic pain syndrome and sexual dysfunction. Andrologiya Genital. Khirurgiya. 2015;16(4):18-26. Russian.
Bianchi-Frias D, Vakar-Lopez F, Coleman IM, Plymate SR, Reed MJ, Nelson PS. The Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment. PLoS One. 2010;5(9):e12501. doi: https://doi.org/10.1371/journal.pone.0012501
Breser ML, Salazar FC, Rivero VE, Motrich RD. Immunological Mechanisms Underlying Chronic Pelvic Pain and Prostate Inflammation in Chronic Pelvic Pain Syndrome. Front. Immunol. 2017;8:898. doi: https://doi.org/10.3389/fimmu.2017.00898
Conti P, Caraffa A, Mastrangelo F, Tettamanti L, Ronconi G, Frydas I, Kritas SK, Theoharides TC. Critical Role of Inflammatory Mast Cell in Fibrosis: Potential Therapeutic Effect of IL-37. Cell Prolif. 2018;51(5):e12475. doi: https://doi.org/10.1111/cpr.12475
Dellabella M, Milanese G, Sigala S, d’Anzeo G, Arrighi N, Bodei S, Muzzonigro G. The role of the prostatic stroma in chronic prostatitis/chronic pelvic pain syndrome. Inflamm. Res. 2009;58(12):829-836. doi: https://doi.org/10.1007/s00011-009-0086-7
Pirola GM, Verdacchi T, Rosadi S, Annino F, De Angelis M. Chronic prostatitis: current treatment options. Res. Rep. Urol. 2019;11:165-174. doi: https://doi.org/10.2147/RRU.S194679
Polackwich AS, Shoskes DA. Chronic prostatitis/chronic pelvic pain syndrome: a review of evaluation and therapy. Prostate Cancer Prostatic Dis. 2016;19(2):132-138. doi: https://doi.org/10.1038/pcan.2016.8
Schuppe HC, Köhn FM. Impact of lifestyle and environmental factors on male reproductive health. Hautarzt. 2018;69(12):996-1005. doi: https://doi.org/10.1007/s00105-018-4307-2
Wang GC, Huang TR, Hu YY, Wang KY, Shi H, Yin L, Peng B. Corpus Cavernosum Smooth Muscle Cell Dysfunction and Phenotype Transformation Are Related to Erectile Dysfunction in Prostatitis Rats With Chronic prostatitis/chronic Pelvic Pain Syndrome. J. Inflamm. (Lond). 2020;17:2. doi: https://doi.org/10.1186/s12950-019-0233-z
Zeng H, He Y, Yu Y, Zhang J, Zeng X, Gong F, Liu Q, Yang B. Resveratrol Improves Prostate Fibrosis During Progression of Urinary Dysfunction in Chronic Prostatitis by Mast Cell Suppression. Mol. Med. Rep. 2018;17(1):918-924. doi: https://doi.org/10.3892/mmr.2017.7960
Zhao F, Ye MY, Zhao JF, Lü BD. Henotypic Modulation of Corporal Cavernosum Smooth Muscle Cells and Erectile Dysfunction: Advances in Studies. Zhonghua Nan Ke Xue. 2018;24(10):927-932.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 9, pp. 388-394, September, 2020
Rights and permissions
About this article
Cite this article
Lapii, G.A., Molodykh, O.P., Abdullaev, N.A. et al. Features of Remodeling of Prostate Stroma in Chronic Abacterial Prostatitis. Bull Exp Biol Med 170, 389–394 (2021). https://doi.org/10.1007/s10517-021-05073-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-021-05073-y