Skip to main content

Advertisement

SpringerLink
Log in

Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity

  • Published:
Chemistry of Natural Compounds Aims and scope

New di-, tri-, tetra-, and pentanorlabdane compounds with thiosemicarbazone and 1,3-thiazole fragments were synthesized. Their antifungal and antibacterial activities were studied. The main advantages of this research were the available starting material, i.e., the natural labdane diterpenoid (–)-sclareol, which was isolated from renewable resources, and the high probability of biological activity combined with the low toxicity of these compounds because of their natural origin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. R. Hanson, Nat. Prod. Rep., 29 (8), 890 (2012).

    Article  CAS  Google Scholar 

  2. I. Chinou, Curr. Med. Chem., 12, 1295 (2005).

    Article  CAS  Google Scholar 

  3. M. Singh, M. Pal, and R. P. Sharma, Planta Med., 65 (1), 2 (1999).

    Article  CAS  Google Scholar 

  4. R. R. Sharipova, O. V. Andreeva, B. F. Garifullin, I. Yu. Strobykina, A. S. Strobykina, A. D. Voloshina, M. A. Kravchenko, and V. E. Kataev, Chem. Nat. Compd., 54, 92 (2018).

    Article  CAS  Google Scholar 

  5. L. E. Catalan, E. B. Maturana, K. C. Marin, M. O. Olivares, H. C. Altamirano, M. C. Cuellar Fritis, and J. V. Garcia, Molecules, 15 (9), 6502 (2010).

    Article  CAS  Google Scholar 

  6. K. Kuchkova, A. Aricu, A. Barba, P. Vlad, S. Shova, E. Secara, N. Ungur, Gh. Zbancioc, and I. I. Mangalagiu, Synlett, 24, 697 (2013).

    Article  CAS  Google Scholar 

  7. A. Aricu, A. Ciocarlan, L. Lungu, A. Barba, S. Shova, G. Zbancioc, I. I. Mangalagiu, M. D’Ambrosio, and N. Vornicu, Med. Chem. Res., 25 (10), 2316 (2016).

  8. H. Beraldo and D. Gambino, Mini-Rev. Med. Chem., 4, 31 (2004).

    Article  CAS  Google Scholar 

  9. A. I. Matesanz, I. Leitao, and P. Souza, J. Inorg. Biochem., 125, 26 (2013).

    Article  CAS  Google Scholar 

  10. A. Rajasekaran and S. Murugesan, J. Indian Chem. Soc., 79 (6), 544 (2002).

    CAS  Google Scholar 

  11. F. Vandresen, H. Falzirolli, S. A. Almeida Batista, A. P. B. da Silva-Giardini, D. N. de Oliveira, R. R. Catharino, A. L. T. G. Ruiz, J. E. de Carvalho, M. A. Foglio, and C. Conceicao da Silva, Eur. J. Med. Chem., 79, 110 (2014).

    Article  CAS  Google Scholar 

  12. V. P. Kirin, V. A. Maksakov, A. V. Virovets, S. A. Popov, and A. V. Tkachev, Inorg. Chem. Commun., 5, 32 (2002).

    Article  CAS  Google Scholar 

  13. S. Blaja, Chem. J. Mold., 14 (2), 72 (2019).

    Article  CAS  Google Scholar 

  14. J. J. Liu, Y. J. Lu, Z. D. Zhao, S. C. Xu, and L. W. Bi, Chem. Nat. Compd., 54, 695 (2018).

    Article  CAS  Google Scholar 

  15. S. K. Hua, J. Wang, X. B. Chen, Z. Y. Xu, and B. B. Zeng, Tetrahedron, 67, 1142 (2011).

    Article  CAS  Google Scholar 

  16. C. Cucicova, A. Aricu, E. Secara, P. Vlad, and N. Ungur, MD Pat. No. 8, 22 (2013).

  17. R. M. Mohareb, W. W. Wardakhan, G. A. Elmegeed, and R. M. S. Ashour, Steroids, 77, 1560 (2012).

    Article  CAS  Google Scholar 

  18. K. Kuchkova, Y. M. Chumakov, Y. A. Simonov, G. Bocelli, A. A. Panasenko, and P. F. Vlad, Synthesis, 9, 1045 (1997).

    Article  Google Scholar 

  19. M. N. Koltsa, G. N. Mironov, S. T. Malinovskii, and P. F. Vlad, Russ. Chem. Bull., 45 (1), 208 (1996).

    Article  Google Scholar 

  20. A. Aricu, A. Ciocarlan, L. Lungu, S. Shova, G. Zbancioc, I. Mangalagiu, and N. Vornicu, Med. Chem. Res., 25 (10), 2316 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

We thank the World Federation of Scientists for financial support of scientific research on the Project “Synthesis, characterization and biological activity of di- and trinorlabdane compounds with 1,3-thiazole units.”

Author information

Authors and Affiliations

  1. Institute of Chemistry, 3 Akademicheskaya St., MD-2028, Kishinev, Moldova

    S. P. Blaja, L. V. Lungu, K. I. Kuchkova, A. G. Ciocarlan, A. N. Barba & A. N. Aricu

  2. Metropolitan Center of Research T. A. B. O. R, 9 Closca St., RO-700066, Iasi, Romania

    N. Vornicu

Authors
  1. S. P. Blaja
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. V. Lungu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. I. Kuchkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. G. Ciocarlan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. N. Barba
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. Vornicu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. N. Aricu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. N. Aricu.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2021, pp. 84–92.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Blaja, S.P., Lungu, L.V., Kuchkova, K.I. et al. Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity. Chem Nat Compd 57, 101–110 (2021). https://doi.org/10.1007/s10600-021-03292-3

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-021-03292-3

Keywords

Search

Navigation