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Takotsubo syndrome: an overview of pathophysiology, diagnosis and treatment with emphasis on cancer patients

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Abstract

Takotsubo syndrome is a disease of great clinical importance that remains underdiagnosed. It is a form of acute heart failure characterized by a transient wall motion abnormality of the left ventricular apex typically triggered by emotional or physical stress. Takotsubo syndrome is commonly associated with cancer and results in poor outcomes. Therefore, early recognition and prompt therapy are essential to improve prognosis. The aim of this manuscript is to review the consequences of the association between cancer and Takotsubo to summarize the available evidence to guide physicians to improve the management of these patients.

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Authors and Affiliations

  1. Department of Cardio-Oncology, Instituto do Câncer do Estado de São Paulo and Instituto do Coracao, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, 01246-903, Brazil

    Isabela Bispo Santos da Silva Costa, Clara Salles Figueiredo, Silvia Moulin Ribeiro Fonseca, Cristina Salvadori Bittar, Carolina Maria Domingues de Carvalho Silva, Stéphanie Itala Rizk, Roberto Kalil Filho & Ludhmila Abrahão Hajjar

  2. Department of Cardiology, Hospital SirioLibanes, São Paulo, Brazil

    Roberto Kalil Filho & Ludhmila Abrahão Hajjar

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  1. Isabela Bispo Santos da Silva Costa
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  2. Clara Salles Figueiredo
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da Silva Costa, I.B.S., Figueiredo, C.S., Fonseca, S.M.R. et al. Takotsubo syndrome: an overview of pathophysiology, diagnosis and treatment with emphasis on cancer patients. Heart Fail Rev 24, 833–846 (2019). https://doi.org/10.1007/s10741-019-09813-1

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