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Retinal layers in prolactinoma patients: a spectral-domain optical coherence tomography study

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Abstract

Purpose

Prolactinoma is a type of pituitary tumour that produces an excessive amount of the hormone prolactin. It is the most common type of hormonally-active pituitary tumour. These tumours can cause ocular complications such as vision loss and visual fields (VF) defect. In this study, we aimed to evaluate the thickness of chorioretinal layers in patients with prolactinoma.

Methods

We enrolled 63 eyes of 32 prolactinoma patients and 36 eyes of 18 age and gender-matched healthy controls. All participants underwent complete hormonal and ophthalmological examination, including spectral-domain optical coherence tomography (SD-OCT) and VF test.The complete biochemical response was defined as serum PRL concentration ≤ 20 ng/mL at the time of evaluation.The seven layers were retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), and retinal pigment epithelium (RPE). The results of prolactinoma patients were compared with the control group.

Results

The mean RNFL, GCL, IPL, INL, ONL, and RPE were thinner in prolactinoma patients than the control group (p < 0.05) while OPL was similar between groups (p > 0.05).None of the patients had VF defect.The thickness of retinal layers was similar in patients with and without complete biochemical response (p > 0.05).

Conclusion

To our knowledge, this is the first study that evaluates the thickness of chorioretinal layers in patients with prolactinoma.Most of the layers were thinner than the control group.Therefore, detailed eye assessment should be a routine component of the follow-up visits of prolactinoma patients and further studies related to this condition are required.

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Funding

This research received no specific grant from any funding agency in the public, commercial, or not for profit sectors.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital, Üniversiteler Mh., Bilkent Blv, 06800, Ankara, Turkey

    Berna Evranos Ogmen, Sefika Burcak Polat, Reyhan Ersoy & Bekir Cakir

  2. Faculty of Medicine, Department of Ophthalmology, Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital, Ankara, Turkey

    Nagihan Ugurlu

  3. Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Ankara, Turkey

    Sevgül Faki

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  1. Berna Evranos Ogmen
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  2. Nagihan Ugurlu
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Correspondence to Berna Evranos Ogmen.

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Ogmen, B.E., Ugurlu, N., Faki, S. et al. Retinal layers in prolactinoma patients: a spectral-domain optical coherence tomography study. Int Ophthalmol 41, 1373–1379 (2021). https://doi.org/10.1007/s10792-021-01701-8

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