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Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review

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Abstract

Colorectal cancer (CRC) is a multifactorial disease commonly diagnosed worldwide, with high mortality rates. Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. All the included studies used RT-PCR (Taqman or SYBR Green) for miR expression analysis and the period of publication was from 2009 to 2018. A total of 115 articles accomplished the inclusion criteria and were included in the review. The studies investigated the expression of 100 different miRs associated with prognostic aspects in colorectal cancer patients. The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the individual miRs in order to use them in clinical practice.

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  1. Igor Lopes dos Santos, Karlla Greick Batista Dias Penna, Megmar Aparecida dos Santos Carneiro, Larisse Silva Dalla Libera, Jéssica Enocencio Porto Ramos and Vera Aparecida Saddi have been contributed equally to this work.

Authors and Affiliations

  1. Programa de Mestrado em Ciências Ambientais e Saúde da Pontifícia Universidade Católica de Goiás, Laboratório de Genética e Biodiversidade, Escola de Ciências Médicas, Farmacêuticas e Biomédicas da Pontifícia Universidade Católica de Goiás, Área IV, Praça Universitária, 1440, Setor Leste Universitário, Goiânia, GO, 74605-010, Brazil

    Igor Lopes dos Santos, Karlla Greick Batista Dias Penna, Jéssica Enocencio Porto Ramos & Vera Aparecida Saddi

  2. Laboratório de Virologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil

    Megmar Aparecida dos Santos Carneiro

  3. Ciências da Saúde, Universidade Federal de Goiás, Goiânia Goiás, Brazil

    Larisse Silva Dalla Libera

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dos Santos, I.L., Penna, K.G.B.D., dos Santos Carneiro, M.A. et al. Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review. Mol Biol Rep 48, 1853–1867 (2021). https://doi.org/10.1007/s11033-020-06075-1

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