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Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1

  • Nephrology - Review
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Abstract

Acute kidney injury (AKI) is a common syndrome associated with high morbidity and mortality, despite progress in medical care. Many studies have shown that there are sex differences and different role of sex hormones particularly estrogens in kidney injury. In this regard, the incidence and rate of progression of kidney diseases are higher in men compared with women. These observations suggest that female sex hormone may be renoprotective. Silent information regulator 2 homolog 1 (SIRT1) is a histone deacetylase, which is implicated in multiple biologic processes in several organisms. In the kidneys, SIRT1 inhibits renal cell apoptosis, inflammation, and fibrosis. Studies have reported a link between SIRT1 and estrogen. In addition, SIRT1 regulates ERα expression and inhibition of SIRT1 activity suppresses ERα expression. This effect leads to inhibition of estrogen-responsive gene expression. In this text, we review the role of SIRT1 in mediating the protective effects of estrogen in the onset and progression of AKI.

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Authors and Affiliations

  1. Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

    Mohammad Khaksari & Alireza Raji-amirhasani

  2. Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

    Fatemeh Darvishzadeh Mahani

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  1. Fatemeh Darvishzadeh Mahani
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Darvishzadeh Mahani, F., Khaksari, M. & Raji-amirhasani, A. Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1. Int Urol Nephrol 53, 2299–2310 (2021). https://doi.org/10.1007/s11255-020-02761-y

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