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Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

Obstructive sleep apnea-hypopnea syndrome (OSAHS) may cause pulmonary diseases, and periostin plays an important role on the development of pulmonary diseases. In addition, periostin and pro-inflammatory cytokine TNF-α can regulate each other in vivo. This study aimed to observe the changes of serum periostin and TNF-α levels in patients with OSAHS compared with healthy volunteers and to investigate their correlation.

Methods

A convenience sample of 67 patients with OSAHS in our hospital from December 2018 to December 2019 was selected and categorized into mild, moderate, and severe groups according to apnea-hypopnea index by polysomnography. In addition, 21 healthy volunteers were selected as the control group. Serum levels of periostin and TNF-α were determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed using the SPSS software.

Results

Both serum periostin and TNF-α levels in all the three OSAHS groups were higher than those of the control group and increased with severity of OSAHS. The severe group had significantly higher serum periostin and TNF-α levels than the mild and moderate groups (p < 0.05). For patients with OSAHS, serum periostin and TNF-α levels positively correlated with the apnea-hypopnea index (AHI) (p < 0.01) and negatively correlated with the lowest saturation oxygen (LSaO2) and mean saturation oxygen (MSaO2) (both p < 0.01). In addition, there was a positive correlation between serum periostin and TNF-α levels in patients with OSAHS (p < 0.001).

Conclusions

Serum periostin and TNF-α levels were significantly increased in patients with OSAHS and may serve as a potential biomarker for severity of OSAHS. These findings suggest that it may be fruitful to study the role of periostin and TNF-α in OSAHS-induced pulmonary diseases.

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References

  1. Qaseem A, Holty JC, Owens DK, Dallas P, Starkey M, Shekelle P (2013) Management of obstructive sleep apnea in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med 159:471–483

    Article  Google Scholar 

  2. McNicholas WT, Bonsignore MR (2007) Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J 29:156–178

    Article  CAS  Google Scholar 

  3. Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90:47–112

    Article  CAS  Google Scholar 

  4. Young T, Peppard PE, Taheri S (2005) Excess weight and sleep-disordered breathing. J Appl Physiol 99:1592–1599

    Article  Google Scholar 

  5. Dean RT, Wilcox I (1993) Possible atherogenic effects of hypoxia during obstructive sleep apnea. Sleep 16:S15–S32

    Article  CAS  Google Scholar 

  6. Dyugovskaya L, Lavie P, Lavie L (2002) Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med 165:934–939

    Article  Google Scholar 

  7. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V (2005) Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353:2034–2041

    Article  CAS  Google Scholar 

  8. Westergren-Thorsson G, Larsen K, Nihlberg K, Andersson-Sjöland A, Hallgren O, Marko-Varga G, Bjermer L (2010) Pathological airway remodelling in inflammation. Clin Respir J 4:1–8

    Article  CAS  Google Scholar 

  9. Knight D (2001) Epithelium–fibroblast interactions in response to airway inflammation. Immunol Cell Biol 79:160–164

    Article  CAS  Google Scholar 

  10. Bonnet N, Garnero P, Ferrari S (2016) Periostin action in bone. Mol Cell Endocrinol 432:75–82

    Article  CAS  Google Scholar 

  11. Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD, Galipeau J (2008) Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. J Biol Chem 283:17991–18001

    Article  CAS  Google Scholar 

  12. Idolazzi L, Ridolo E, Fassio A, Gatti D, Montagni M, Caminati M, Martignago I, Incorvaia C, Senna G (2017) Periostin: the bone and beyond. Eur J Intern Med 38:12–16

    Article  CAS  Google Scholar 

  13. Liu AY, Zheng H, Ouyang G (2014) Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol 37:150–156

    Article  Google Scholar 

  14. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV (2007) Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci 104:15858–15863

    Article  CAS  Google Scholar 

  15. Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, Ohta S, Kato S, Izuhara K, Aizawa H (2011) Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. Eur Respir J 37:1119–1127

    Article  CAS  Google Scholar 

  16. Nakajima M, Honda T, Miyauchi S, Yamazaki K (2014) Th2 cytokines efficiently stimulate periostin production in gingival fibroblasts but periostin does not induce an inflammatory response in gingival epithelial cells. Arch Oral Biol 59:93–101

    Article  CAS  Google Scholar 

  17. Sozmen M, Devrim AK, Kabak YB, Devrim T (2019) Periostin alters transcriptional profile in a rat model of isoproterenol-induced cardiotoxicity. Hum Exp Toxicol 38:255–266

    Article  CAS  Google Scholar 

  18. Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, Harrod CG (2017) Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of sleep medicine clinical practice guideline. J Clin Sleep Med 13:479–504

    Article  Google Scholar 

  19. Meslier N, Gagnadoux F, Giraud P, Person C, Ouksel H, Urban T, Racineux JL (2003) Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur Respir J 22:156–160

    Article  CAS  Google Scholar 

  20. Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M (2013) Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol 132:305–312

    Article  CAS  Google Scholar 

  21. Generoso A, Oppenheimer J (2020) Asthma/obstructive pulmonary disease overlap: update on definition, biomarkers, and therapeutics. Curr Opin Allergy Clin Immunol 20:43–47

    Article  CAS  Google Scholar 

  22. Desai M, Oppenheimer J, Tashkin DP (2017) Asthma-chronic obstructive pulmonary disease overlap syndrome: what we know and what we need to find out. Ann Allergy Asthma Immunol 118:241–245

    Article  Google Scholar 

  23. He ZH, Domany KA, Nava-Guerra L, Khoo MCK, DiFrancesco M, Xu YF, McConnell K, Hossain MM, Amin R (2019) Phenotype of ventilatory control in children with moderate to severe persistent asthma and obstructive sleep apnea. Sleep 42:UNSP zsz130

    Article  Google Scholar 

  24. Ding X, Yu C, Liu Y, Yan S, Li W, Wang D, Sun L, Han Y, Li M, Zhang S, Yun F, Zhao H, Li Y (2014) Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-β/miR-185/CoLA1 signaling in a canine model. Oncotarget 7:57545–57555

  25. Broytman O, Braun RK, Morgan BJ, Egelow DF, Hsu PN, Mei LS, Koya AK, Eldridge M, Teodorescu M (2015) Effects of chronic intermittent hypoxia on allergen-induced airway inflammation in rats. Am J Respir Cell Mol Biol 52:162–170

    Article  Google Scholar 

  26. Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, Kudo A (2010) Incroporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chen 285:2028–2039

    Article  CAS  Google Scholar 

  27. O’Dwyer DN, Moore BB (2017) The role of periostin in lung fibrosis and airway remodeling. Cell Mol Life Sci 74:4305–4314

    Article  Google Scholar 

  28. Li NF, Yao XG, Zhu J, Yang J, Liu KJ, Wang YC, Wang XL, Zu FY (2010) Higher levels of plasma TNF-α and neuropeptide Y in hypertensive patients with obstructive sleep apnea syndrome. Clin Exp Hypertens 32:54–60

    Article  Google Scholar 

  29. Minoguchi K, Tazaki T, Yokoe T, Minoguchi H, Watanabe Y, Yamamoto M, Mitsuru A (2004) Elevated production of tumor necrosis factor-alpha by monocytes in patients with obstructive sleep apnea syndrome. Chest 126:1473–1479

    Article  CAS  Google Scholar 

  30. Luo Y, Qu H, Wang H, Wei H, Wu J, Duan Y, Liu D, Deng H (2016) Plasma periostin levels are increased in Chinese subjects with obesity and type 2 diabetes and are positively correlated with glucose and lipid parameters. Mediat Inflamm 2016:6423637

    Google Scholar 

  31. Amara S, Lopez K, Banan B, Brown SK, Whalen M, Myles E, Lvy MT, Johnson T, Schey KL, Tiriveedhi V (2015) Synergistic effect of proinflammatory TNF-α and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis. Mol Immunol 64:26–35

    Article  CAS  Google Scholar 

Download references

Funding

The authors received financial support and grants from the National Natural Science Foundation of China (81600044), the Six Talent Peaks Project in Jiangsu Province (WSN-081), and Xuzhou City Bureau of Science and Technology Project (KC KC18058).

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Author notes

  1. Lei Ji and Yanan Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Respiratory Medicine, Affiliated Hospital of Xuzhou Medical University, 99 Huaihai Road, Xuzhou, 221000, China

    Lei Ji, Yanan Liu, Pingli Liu, Guijuan Ji, Jun He, Yuying Gan, Shuyang Zhu, Bi Chen & Wenhui Zhang

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  1. Lei Ji
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  2. Yanan Liu
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  3. Pingli Liu
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  4. Guijuan Ji
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  7. Shuyang Zhu
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Correspondence to Bi Chen or Wenhui Zhang.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Ji, L., Liu, Y., Liu, P. et al. Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Breath 25, 331–337 (2021). https://doi.org/10.1007/s11325-020-02124-y

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  • DOI: https://doi.org/10.1007/s11325-020-02124-y

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