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C Peptide Fails to Improve the Utility of the DiaRem Algorithm in Predicting Remission of Type II Diabetes After Bariatric Surgery

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Abstract

We evaluated the utility of C peptide as an addition to the DiaRem score for predicting type 2 diabetes (T2D) remission 1 year after bariatric surgery in 175 patients. DiaRem score was significantly correlated with C peptide (r = − .43; p < .001). Both DiaRem and C peptide were significant predictors of remission of T2D (OR (95% CI) = .81 (.75–.86); p < 0001 and OR (95% CI) = 1.35 (1.15–1.60); p < .001, respectively). ROC analysis indicated that DiaRem was a significantly stronger predictor than C peptide (p < .001). Hierarchical regression indicated that C peptide failed to significantly improve the prediction of diabetes remission after accounting for DiaRem (OR (95% CI) = 1.079 (.87–1.26); p = .406). This study does not support the inclusion of C peptide in the DiaRem algorithm.

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Authors and Affiliations

  1. Hartford Healthcare Surgical Weight Loss Center, Hartford, CT, 06102, USA

    Richard L. Seip, Tara McLaughlin, Madison O’Brien, Devika Umashanker, Darren Tishler & Pavlos K. Papasavas

  2. Hartford Healthcare Research Program, Hartford, CT, 06102, USA

    Ilene Staff

  3. Hartford Healthcare Medical Group, Farmington, CT, 06032, USA

    Aashish Samat

  4. Hartford Healthcare Surgical Weight Loss Center, 330 Western Blvd., Glastonbury, CT, 06033, USA

    Pavlos K. Papasavas

Authors
  1. Richard L. Seip
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  2. Tara McLaughlin
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  3. Madison O’Brien
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  4. Ilene Staff
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  5. Aashish Samat
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  6. Devika Umashanker
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  7. Darren Tishler
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  8. Pavlos K. Papasavas
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Corresponding author

Correspondence to Pavlos K. Papasavas.

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Conflict of Interest

RLS: no conflict of interest. TM: no conflict of interest. MO: no conflict of interest. IS: no conflict of interest. AS: no conflict of interest. DU: no conflict of interest. DT served as a consultant for Olympus, Medtronic, Conmed and Intuitive. PKP: no conflict of interest.

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Informed consent does not apply. This study was approved by the Institutional Review Board with a waiver of informed consent.

Ethical Approval

This study was approved by the Institutional Review Board. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Seip, R.L., McLaughlin, T., O’Brien, M. et al. C Peptide Fails to Improve the Utility of the DiaRem Algorithm in Predicting Remission of Type II Diabetes After Bariatric Surgery. OBES SURG 31, 2807–2811 (2021). https://doi.org/10.1007/s11695-021-05227-x

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  • DOI: https://doi.org/10.1007/s11695-021-05227-x

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