Abstract
Background
Patients with a severe acute brain injury admitted to the intensive care unit often have a poor neurological prognosis. In these situations, a clinician is responsible for conducting a goals-of-care conversation with the patient’s surrogate decision makers. The diversity in thought and background of surrogate decision makers can present challenges during these conversations. For this reason, our study aimed to identify predictive characteristics of US surrogate decision makers’ favoring life-sustaining treatment (LST) over comfort measures only for patients with severe acute brain injury.
Methods
We analyzed data from a cross-sectional survey study that had recruited 1588 subjects from an online probability-based US population sample. Seven hundred and ninety-two subjects had randomly received a hypothetical scenario regarding a relative intubated with severe acute brain injury with a prognosis of severe disability but with the potential to regain some consciousness. Seven hundred and ninety-six subjects had been randomized to a similar scenario in which the relative was projected to remain vegetative. For each scenario, we conducted univariate analyses and binary logistic regressions to determine predictors of LST selection among available respondent characteristics.
Results
15.0% of subjects selected LST for the severe disability scenario compared to 11.4% for the vegetative state scenario (p = 0.07), with those selecting LST in both groups expressing less decisional certainty. For the severe disability scenario, independent predictors of LST included having less than a high school education (adjusted OR = 2.87, 95% CI = 1.23–6.76), concern regarding prognostic accuracy (7.64, 3.61–16.15), and concern regarding the cost of care (4.07, 1.80–9.18). For the vegetative scenario, predictors included the youngest age group (30–44 years, 3.33, 1.02–10.86), male gender (3.26, 1.75–6.06), English as a second language (2.94, 1.09–7.89), Evangelical Protestant (3.72, 1.28–10.84) and Catholic (4.01, 1.72–9.36) affiliations, and low income (< $25 K).
Conclusion
Several demographic and decisional characteristics of US surrogate decision makers predict LST selection for patients with severe brain injury with varying degrees of poor prognosis. Surrogates concerned about the cost of medical care may nevertheless be inclined to select LST, albeit with high levels of decisional uncertainty, for patients projected to have severe disabilities.
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References
Creutzfeldt CJ, Engelberg RA, Healey L, et al. Palliative care needs in the neuro-ICU. Crit Care Med. 2015;43(8):1677–84.
Schaefer. Neuro-palliative care. Pflege. 2012;25(2):144–6. https://doi.org/10.1007/978-3-319-93215-6.
Cai X, Robinson J, Muehlschlegel S, et al. Patient preferences and surrogate decision making in neuroscience intensive care units. Neurocrit Care. 2015;23(1):131–41.
Kon AA, Davidson JE, Morrison W, et al. Shared decision making in ICUs: an American College of Critical Care Medicine and American Thoracic Society policy statement. Crit Care Med. 2016;44(1):188–201.
Khan MW, Muehlschlegel S. Shared decision making in neurocritical care. Neurosurg Clin N Am. 2018;29(2):315–21.
Cook DJ. Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill. JAMA J Am Med Assoc. 1995;273(9):703.
Daly BJ, Douglas SL, O’Toole E, et al. Complexity analysis of decision-making in the critically ill. J Intensive Care Med. 2018;33(10):557–66.
Sharman M, Meert KL, Sarnaik AP. What influences parents? Decisions to limit or withdraw life support?*. Pediatr Crit Care Med. 2005;6(5):513–8.
Quinn T, Moskowitz J, Khan MW, et al. What families need and physicians deliver: contrasting communication preferences between surrogate decision-makers and physicians during outcome prognostication in critically Ill TBI patients. Neurocrit Care. 2017;27(2):154–62. https://doi.org/10.1007/s12028-017-0427-2.
Turgeon AF, Dorrance K, Archambault P, et al. Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury. Can Med Assoc J. 2019;191(24):E652–63.
Wendler D, Rid A. Systematic review: the effect on surrogates of making treatment decisions for others. Ann Intern Med. 2011;154(5):336.
Hwang DY, Knies AK, Mampre D, et al. Concerns of surrogate decision makers for acute brain injury patients: a US population survey. Neurology 2020.
IPSOS. 10 Differentiators of the IPSOS KnowledgePanel®. 2020 [cited 2020 Jul 1]; p. 1–2. https://www.ipsos.com/sites/default/files/20-04-55_10diff_v4.pdf.
Flynn TN, Marley AAJ. Best-worst scaling: theory and methods. In: Handbook of choice modelling. Edward Elgar Publishing; 2014. p. 178–201. https://econpapers.repec.org/RePEc:elg:eechap:14820_8.
Flynn TN, Louviere JJ, Peters TJ, Coast J. Best-worst scaling: what it can do for health care research and how to do it. J Health Econ. 2007;26(1):171–89. https://doi.org/10.1016/j.jhealeco.2006.04.002.
McCutcheon A. Latent Class Analysis [Internet]. First Edit. Thousand Oaks, California: 1987.
Bardach N, Zhao S, Pantilat S, Johnston SC. Adjustment for do-not-resuscitate orders reverses the apparent in-hospital mortality advantage for minorities. Am J Med. 2005;118(4):400–8.
Garrett JM, Harris RP, Norburn JK, Patrick DL, Danis M. Life-sustaining treatments during terminal illness. J Gen Intern Med. 1993;8(7):361–8. https://doi.org/10.1007/BF02600073.
Stream S, Nolan A, Kwon S, Constable C. Factors associated with combined do-not-resuscitate and do-not-intubate orders: A retrospective chart review at an urban tertiary care center. Resuscitation. 2018;130:1–5.
Qureshi AI, Adil MM, Suri MFK. Rate of use and determinants of withdrawal of care among patients with subarachnoid hemorrhage in the United States. World Neurosurg. 2014;82(5):e579–84.
Blackhall LJ, Frank G, Murphy ST, Michel V, Palmer JM, Azen SP. Ethnicity and attitudes towards life sustaining technology. Soc Sci Med. 1999;48(12):1779–89.
Cardenas-Turanzas M, Gaeta S, Ashoori A, Price KJ, Nates JL. Demographic and clinical determinants of having do not resuscitate orders in the intensive care unit of a comprehensive cancer center. J Palliat Med. 2011;14(1):45–50. https://doi.org/10.1089/jpm.2010.0165.
Chen Y, Criss SD, Watson TR, et al. Cost and utilization of lung cancer end-of-life care among racial-ethnic minority groups in the United States. Oncologist. 2020. https://doi.org/10.1634/theoncologist.2019-0303.
Hopp FP, Duffy SA. Racial variations in end-of-life care. J Am Geriatr Soc. 2000;48(6):658–63. https://doi.org/10.1111/j.1532-5415.2000.tb04724.x.
Johnson RW, Newby LK, Granger CB, et al. Differences in level of care at the end of life according to race. Am J Crit Care. 2010;19(4):335–43. https://doi.org/10.4037/ajcc2010161.
Ormseth CH, Falcone GJ, Jasak SD, et al. Minority patients are less likely to undergo withdrawal of care after spontaneous intracerebral hemorrhage. Neurocrit Care. 2018;29(3):419–25. https://doi.org/10.1007/s12028-018-0554-4.
Cooper Z, Rivara FP, Wang J, MacKenzie EJ, Jurkovich GJ. Racial disparities in intensity of care at the end-of-life: are trauma patients the same as the rest? J Health Care Poor Underserved. 2012;23(2):857–74.
Zahuranec DB, Brown DL, Lisabeth LD, et al. Ethnic differences in do-not-resuscitate orders after intracerebral hemorrhage. Crit Care Med. 2009;37(10):2807–11.
Zurasky JA, Aiyagari V, Zazulia AR, Shackelford A, Diringer MN. Early mortality following spontaneous intracerebral hemorrhage. Neurology. 2005;64(4):725–7. https://doi.org/10.1212/01.WNL.0000152045.56837.58.
Murthy SB, Moradiya Y, Hanley DF, Ziai WC. Palliative care utilization in nontraumatic intracerebral hemorrhage in the United States*. Crit Care Med. 2016;44(3):575–82.
Brown CE, Engelberg RA, Sharma R, et al. Race/ethnicity socioeconomic status, and healthcare intensity at the end of life. J Palliat Med. 2018;21(9):1308–16.
Rhodes RL, Batchelor K, Lee SC, Halm EA. Barriers to end-of-life care for African Americans from the providers’ perspective. Am J Hosp Palliat Med. 2015;32(2):137–43. https://doi.org/10.1177/1049909113507127.
Yancu CN, Farmer DF, Leahman D. Barriers to hospice use and Palliative care services use by African American adults. Am J Hosp Palliat Med 2010.
Boyd EA, Lo B, Evans LR, et al. “It’s not just what the doctor tells me:” Factors that influence surrogate decision-makers’ perceptions of prognosis*. Crit Care Med. 2010;38(5):1270–5.
Meeker MA, Jezewski MA. Metasynthesis: withdrawing life-sustaining treatments: the experience of family decision-makers. J Clin Nurs. 2009;18(2):163–73.
White DB, Carson S, Anderson W, et al. A multicenter study of the causes and consequences of optimistic expectations about prognosis by surrogate decision-makers in ICUs*. Crit Care Med. 2019;47(9):1184–93.
Sjokvist P, Berggren L, Cook DJ. Attitudes of Swedish physicians and nurses towards the use of life-sustaining treatment. Acta Anaesthesiol Scand 1999.
Zier LS. Surrogate Decision Makers’ Interpretation of Prognostic Information. Ann Intern Med. 2012;156(5):360. https://doi.org/10.7326/0003-4819-156-5-201203060-00008.
Chapman AR, Litton E, Chamberlain J, Ho KM. The effect of prognostic data presentation format on perceived risk among surrogate decision makers of critically ill patients: A randomized comparative trial. J Crit Care 2015.
Khandelwal N, Hough CL, Downey L, et al. Prevalence, risk factors, and outcomes of financial stress in survivors of critical illness. Crit Care Med. 2018;46(6):e530–9.
Hauschildt KE, Seigworth C, Kamphuis LA, et al. Financial toxicity after acute respiratory distress syndrome: a national qualitative cohort study*. Crit Care Med. 2020;48(8):1103–10. https://doi.org/10.1097/CCM.00000000000043.
Funding
Dr. Hwang reports other funding from American Brain Foundation, grants from the Neurocritical Care Society, and grants from the Apple Pickers Foundation during the conduct of the study. Dr. Fraenkel reports grants from the Rheumatology Research Foundation and grants from the National Institute of Arthritis and Musculoskeletal and Skin Disease during the conduct of the study (AR060231-06). Dr. White reports grants from the National Heart, Lung, and Blood Institute during the conduct of the study (K24 mentoring award HL148314).
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DYH and LF were involved in conceptualization; AKK, DBW, RGH, and KNS were involved in methodology; DYH, SK, and MS contributed to formal analysis and investigation; AG and AS contributed to writing—original draft preparation; AG, ALS, AKK, SK, MS, HH, DBW, RGH, KNS, LF, and DYH contributed to writing—review and editing; DYH, DBW, RGH, KNS, and LF were involved in funding acquisition; DYH, HH, KNS, and LF were involved in resources; and DYH, HH, KNS, and LF were involved in supervision.
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This study was approved by the Yale Human Investigation Committee (protocols #1406014207 and #1505015893). Because this is a minimal risk study, participants indicated consent by completing the survey after being presented with an introductory page that included all of the essential components of informed consent.
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Informed consent was obtained from all individual participants included in the study.
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Garg, A., Soto, A.L., Knies, A.K. et al. Predictors of Surrogate Decision Makers Selecting Life-Sustaining Therapy for Severe Acute Brain Injury Patients: An Analysis of US Population Survey Data. Neurocrit Care 35, 468–479 (2021). https://doi.org/10.1007/s12028-021-01200-9
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DOI: https://doi.org/10.1007/s12028-021-01200-9