Skip to main content

Advertisement

SpringerLink
Log in

Staged Surgical Resection of Primary Pulmonary Synovial Sarcoma with Synchronous Multiple Pancreatic Metastases: Report of a Rare Case and Review of the Literature

  • Case Report
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Mastrangelo G, Coindre JM, Ducimetiere F, Dei Tos AP, Fadda E, Blay JY, et al. Incidence of soft tissue sarcoma and beyond: a population-based prospective study in 3 European regions. Cancer. 2012;118:5339–48. https://doi.org/10.1002/cncr.27555.

    Article  PubMed  Google Scholar 

  2. Singer S, Baldini EH, Demetri GD, Fletcher JA. Corson JM Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival. J Clin Oncol. 1996;14:1201–8. https://doi.org/10.1200/JCO.1996.14.4.1201.

    Article  CAS  PubMed  Google Scholar 

  3. Mastoraki A, Schizas D, Papanikolaou IS, Bagias G, Machairas N, Agrogiannis G, et al. Management of primary retroperitoneal synovial sarcoma: a case report and review of literature. World J Gastrointest Surg. 2019;11:27–33. https://doi.org/10.4240/wjgs.v11.i1.27.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Haldar M, Hancock JD, Coffin CM, Lessnick SL. Capecchi MR A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell. 2007;11:375–88. https://doi.org/10.1016/j.ccr.2007.01.016.

    Article  CAS  PubMed  Google Scholar 

  5. Stacchiotti S. Van Tine BA Synovial sarcoma: current concepts and future perspectives. J Clin Oncol. 2018;36:180–7. https://doi.org/10.1200/JCO.2017.75.1941.

    Article  CAS  PubMed  Google Scholar 

  6. Thway K. Fisher C Synovial sarcoma: defining features and diagnostic evolution. Ann Diagn Pathol. 2014;18:369–80. https://doi.org/10.1016/j.anndiagpath.2014.09.002.

    Article  PubMed  Google Scholar 

  7. Krieg AH, Hefti F, Speth BM, Jundt G, Guillou L, Exner UG, et al. Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Ann Oncol. 2011;22:458–67. https://doi.org/10.1093/annonc/mdq394.

    Article  CAS  PubMed  Google Scholar 

  8. Etienne-Mastroianni B, Falchero L, Chalabreysse L, Loire R, Ranchere D, Souquet PJ, et al. Primary sarcomas of the lung: a clinicopathologic study of 12 cases. Lung Cancer. 2002;38:283–9. https://doi.org/10.1016/s0169-5002(02)00303-3.

    Article  PubMed  Google Scholar 

  9. Machairas N, Paspala A, Schizas D, Ntomi V, Moris D, Tsilimigras DI, et al. Metastatic squamous cell carcinoma to the pancreas: Report of an extremely rare case. Mol Clin Oncol. 2019;10:144–6. https://doi.org/10.3892/mco.2018.1756.

    Article  PubMed  Google Scholar 

  10. Reddy S. Wolfgang CL The role of surgery in the management of isolated metastases to the pancreas. Lancet Oncol. 2009;10:287–93. https://doi.org/10.1016/S1470-2045(09)70065-8.

    Article  PubMed  Google Scholar 

  11. Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C, et al. Metastatic tumors in the pancreas in the modern era. J Am Coll Surg. 2010;211:749–53. https://doi.org/10.1016/j.jamcollsurg.2010.08.017.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250:187–96. https://doi.org/10.1097/SLA.0b013e3181b13ca2.

    Article  Google Scholar 

  13. A Paspala ID Kostakis A Gaitanidis A Prodromidou D Schizas N Machairas 2019 Long-term outcomes after hepatic and pancreatic resections for metastases from thyroid cancer: a systematic review of the literature J Gastrointest Cancer 50 9 15 https://doi.org/10.1007/s12029-018-00196-4.

  14. Crippa S, Angelini C, Mussi C, Bonardi C, Romano F, Sartori P, et al. Surgical treatment of metastatic tumors to the pancreas: a single center experience and review of the literature. World J Surg. 2006;30:1536–42. https://doi.org/10.1007/s00268-005-0464-4.

    Article  PubMed  Google Scholar 

  15. Schmidt CM, Powell ES, Yiannoutsos CT, Howard TJ, Wiebke EA, Wiesenauer CA, et al. Pancreaticoduodenectomy: a 20-year experience in 516 patients. Arch Surg 2004. 139:718–25; discussion 25–7. https://doi.org/10.1001/archsurg.139.7.718.

  16. Pannala R, Hallberg-Wallace KM, Smith AL, Nassar A, Zhang J, Zarka M, et al. Endoscopic ultrasound-guided fine needle aspiration cytology of metastatic renal cell carcinoma to the pancreas: a multi-center experience. Cytojournal. 2016;13:24. https://doi.org/10.4103/1742-6413.192191.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Dewanwala A, Kotowski A, LeVea CM. Ma WW Secondary tumors of the pancreas: case report and a single-center experience. J Gastrointest Cancer. 2012;43(Suppl 1):S117–24. https://doi.org/10.1007/s12029-011-9317-6.

    Article  PubMed  Google Scholar 

  18. Takenaka S, Ueda T, Naka N, Araki N, Hashimoto N, Myoui A, et al. Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan. Oncol Rep. 2008;19:467–76.

    PubMed  Google Scholar 

  19. Kawai A, Woodruff J, Healey JH, Brennan MF, Antonescu CR. Ladanyi M SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med. 1998;338:153–60. https://doi.org/10.1056/NEJM199801153380303.

    Article  CAS  PubMed  Google Scholar 

  20. Hiotis SP, Klimstra DS, Conlon KC. Brennan MF Results after pancreatic resection for metastatic lesions. Ann Surg Oncol. 2002;9:675–9.

    Article  Google Scholar 

  21. Bassi C, Butturini G, Falconi M, Sargenti M, Mantovani W. Pederzoli P High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma. Br J Surg. 2003;90:555–9. https://doi.org/10.1002/bjs.4072.

    Article  CAS  PubMed  Google Scholar 

  22. Zerbi A. Pecorelli N Pancreatic metastases: an increasing clinical entity. World J Gastrointest Surg. 2010;2:255–9. https://doi.org/10.4240/wjgs.v2.i8.255.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Minni F, Casadei R, Perenze B, Greco VM, Marrano N, Margiotta A, et al. Pancreatic metastases: observations of three cases and review of the literature. Pancreatology. 2004;4:509–20. https://doi.org/10.1159/000080248.

    Article  PubMed  Google Scholar 

  24. Vlenterie M, Litiere S, Rizzo E, Marreaud S, Judson I, Gelderblom H, et al. Outcome of chemotherapy in advanced synovial sarcoma patients: review of 15 clinical trials from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group; setting a new landmark for studies in this entity. Eur J Cancer. 2016;58:62–72. https://doi.org/10.1016/j.ejca.2016.02.002.

    Article  PubMed  Google Scholar 

  25. Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A. Ghert M A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer. 2008;113:573–81. https://doi.org/10.1002/cncr.23592.

    Article  PubMed  Google Scholar 

  26. Makino Y, Shigekawa M, Kegasawa T, Suda T, Yoshioka T, Iwahashi K, et al. A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy. Medicine (Baltimore). 2016;95:e4789. https://doi.org/10.1097/MD.0000000000004789.

    Article  Google Scholar 

  27. Yamamoto H, Watanabe K, Nagata M, Honda I, Watanabe S, Soda H, et al. Surgical treatment for pancreatic metastasis from soft-tissue sarcoma: report of two cases. Am J Clin Oncol. 2001;24:198–200. https://doi.org/10.1097/00000421-200104000-00019.

    Article  CAS  PubMed  Google Scholar 

  28. Lee M, Song JS, Hong SM, Jang SJ, Kim J, Song KB, et al. Sarcoma metastasis to the pancreas: experience at a single institution. J Pathol Transl Med. 2020;54:220–7. https://doi.org/10.4132/jptm.2020.03.04.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We would like to thank Prof. Periklis Tomos for his thoracosurgical consultation and contribution to the treatment of the patient.

Author information

Authors and Affiliations

  1. Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Medical School, Athens, Greece

    Panagiotis Dorovinis, Nikolaos Machairas, Stylianos Kykalos, Paraskevas Stamopoulos, Nikolaos Nikiteas & Georgios C. Sotiropoulos

  2. Department of Pathology, National and Kapodistrian University of Athens, Medical School, Athens, Greece

    George Agrogiannis

Authors
  1. Panagiotis Dorovinis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nikolaos Machairas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stylianos Kykalos
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Paraskevas Stamopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. George Agrogiannis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nikolaos Nikiteas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Georgios C. Sotiropoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nikolaos Machairas.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dorovinis, P., Machairas, N., Kykalos, S. et al. Staged Surgical Resection of Primary Pulmonary Synovial Sarcoma with Synchronous Multiple Pancreatic Metastases: Report of a Rare Case and Review of the Literature. J Gastrointest Canc 52, 1151–1155 (2021). https://doi.org/10.1007/s12029-021-00604-2

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-021-00604-2

Search

Navigation