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[Fesipmim]Cl as highly efficient and reusable catalyst for solventless synthesis of dihydropyridine derivatives through Hantzsch reaction

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Abstract

In the present investigation, magnetic ferrite nanoparticles (ferrite NPs) were synthesized and coated with silica (ferrite@SiO2NPs) by using the sol-gel method. After that, silica propylmethylimidazolium chloride ionic liquid [Sipmim]Cl was prepared and linked with the above-prepared ferrite@SiO2NPs to synthesize ferrite silica propylmethylimidazolium chloride [Fesipmim]Cl catalyst. The formation of [Fesipmim]Cl catalyst was confirmed by Fourier-transform infrared (FT-IR) spectroscopy analysis. X-ray diffraction (XRD) analysis confirmed the structure of ferrite NPs and ferrite@SiO2 NPs. Transmission electron microscopy (TEM) evidenced the successful formation of ferrite NPs and ferrite@SiO2 NPs. Scanning electron microscopy (SEM) results revealed the change in morphology of ferrite NPs, ferrite@SiO2NPs and [Fesipmim]Cl. The magnetic properties of [Fesipmim]Cl catalyst were measured by vibrating sample magnetometer (VSM). The efficiency of the [Fesipmim]Cl catalyst was checked by using it for the synthesis of different derivatives of dihydropyridine through Hantzsch reaction via a three-component coupling reaction of substituted benzaldehydes, ethyl/ methyl acetoacetate and ammonium acetate. The formation and structures of all the synthesized compounds were confirmed by FT-IR, 1HNMR, 13C NMR spectral analyses. The reusability of the catalyst [Fesipmim]Cl was checked up to seven cycles and found to have excellent activity up to five cycles.

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Acknowledgements

The authors wish to thank Govind Ballabh Pant University of Agriculture& Technology, Pantnagar for providing necessary research facilities and KIET Group of Institutions for time to time help and support for completing the research work. Authors also thank AIRF-JNU Delhi and IIT Ropar for providing NMR spectra and ISFAL, Moga for Providing IR spectra and IIT Roorkee for TEM, SEM, XRD and VSM analysis.

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  1. Department of Chemistry, KIET Group of Institutions, Delhi-NCR, Meerut Road (NH-58), Ghaziabad, 201 206, India

    Akansha Agrwal

  2. Department of Chemistry, G. B. Pant University of Agriculture and Technology, Pantnagar, India

    Virendra Kasana

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  1. Akansha Agrwal
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  2. Virendra Kasana
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Correspondence to Akansha Agrwal.

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Agrwal, A., Kasana, V. [Fesipmim]Cl as highly efficient and reusable catalyst for solventless synthesis of dihydropyridine derivatives through Hantzsch reaction. J Chem Sci 132, 67 (2020). https://doi.org/10.1007/s12039-020-01770-9

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