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Intratumoral heterogeneity of FLCN somatic mutations in gastric and colorectal cancers

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Pathology & Oncology Research

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References

  1. Hartman TR, Nicolas E, Klein-Szanto A, Al-Saleem T, Cash TP, Simon MC, Henske EP (2009) The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene 28:1594–1604

    Article  CAS  Google Scholar 

  2. Khoo SK, Giraud S, Kahnoski K, Chen J, Motorna O, Nickolov R, Binet O, Lambert D, Friedel J, Lévy R, Ferlicot S, Wolkenstein P, Hammel P, Bergerheim U, Hedblad MA, Bradley M, Teh BT, Nordenskjöld M, Richard S (2002) Clinical and genetic studies of Birt-Hogg-Dubé syndrome. J Med Genet 39:906–912

    Article  CAS  Google Scholar 

  3. Kahnoski K, Khoo SK, Nassif NT, Chen J, Lobo GP, Segelov E, Teh BT (2003) Alterations of the Birt-Hogg-Dubé gene (BHD) in sporadic colorectal tumours. J Med Genet 40:511–515

    Article  CAS  Google Scholar 

  4. Shin JH, Shin YK, Ku JL, Jeong SY, Hong SH, Park SY, Kim WH, Park JG (2003) Mutations of the Birt-Hogg-Dubé (BHD) gene in sporadic colorectal carcinomas and colorectal carcinoma cell lines with microsatellite instability. J Med Genet 40:364–367

    Article  CAS  Google Scholar 

  5. Imai K, Yamamoto H (2008) Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29:673–680

    Article  CAS  Google Scholar 

  6. Choi EJ, Kim MS, Song SY, Yoo NJ, Lee SH (2017) Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability. Pathol Oncol Res 23:145–149

    Article  CAS  Google Scholar 

  7. McGranahan N, Swanton C (2015) Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell 27:15–26

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by a grant from National Research Foundation of Korea (2019R1A5A2027588).

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Authors and Affiliations

  1. Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, 137-701, Seoul, Korea

    Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo & Sug Hyung Lee

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  1. Hyun Ji Son
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  2. Eun Ji Choi
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  3. Nam Jin Yoo
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Correspondence to Sug Hyung Lee.

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Son, H.J., Choi, E.J., Yoo, N.J. et al. Intratumoral heterogeneity of FLCN somatic mutations in gastric and colorectal cancers. Pathol. Oncol. Res. 26, 2811–2812 (2020). https://doi.org/10.1007/s12253-019-00774-2

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