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Recurrent Respiratory Papillomatosis

  • PEDIATRIC OTOLARYNGOLOGY: Pediatric Airway and Voice (J Ongkasuwan, Section Editor)
  • Published:
Current Otorhinolaryngology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Recurrent respiratory papillomatosis (RRP) is a rare disease that continues to cause significant morbidity and occupies a disproportionate amount of otolaryngology care relative to its incidence. As there is no cure for the disease process once it has manifested, recent efforts continue to focus on treatment modalities that delay papilloma re-growth.

Recent Findings

Systemic bevacizumab has been used off-label in severe cases of juvenile RRP with profound reduction in disease volume; however, it requires maintenance therapy of unknown duration. An international adoption of HPV vaccination has led to a decreased incidence of RRP and could potentially eradicate the disease entirely if herd immunity is reached in the USA.

Summary

RRP remains a disease with significant morbidity and few successful long-term treatment modalities. For severe cases, systemic bevacizumab shows promise, but comes at significant cost. Ultimately, nationwide HPV vaccination will be the most successful measure to eradicate this disease entirely.

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Authors and Affiliations

  1. Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Blvd, Wood Building, Philadelphia, PA, 19103, USA

    Ryan Ruiz & Karen B. Zur

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  1. Ryan Ruiz
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  2. Karen B. Zur
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Correspondence to Karen B. Zur.

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This article is part of the Topical Collection on PEDIATRIC OTOLARYNGOLOGY: Pediatric Airway and Voice

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Ruiz, R., Zur, K.B. Recurrent Respiratory Papillomatosis. Curr Otorhinolaryngol Rep 9, 23–28 (2021). https://doi.org/10.1007/s40136-020-00328-0

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  • DOI: https://doi.org/10.1007/s40136-020-00328-0

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