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Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population

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Abstract

Background

Type 2 diabetes mellitus is a serious public health problem worldwide. The aim of the study was to analyze the relationship of eight polymorphic gene variants with the development of clinical-metabolic rates of type 2 diabetes mellitus inside Kazakh population.

Materials and methods

139 patients with type 2 diabetes mellitus and 100 patients in the control group were examined. Genotyping of polymorphisms of candidate genes was carried out on a next generation QuantStudio 12 K Flex unit.

Results

Gene TCF7L2 locus rs7901695 and rs7903146, gene KCNQ1 locus rs2237892, rs7756992, and gene CDKAL1 locus rs7754840 demonstrated statistically significant associations with glucose metabolism, lipid profile and body mass index (BMI) in type 2 DM inside the population. Statistically significant difference in anthropometric and biochemical measures of rs17584499, rs4712523 and rs163184 has not been revealed.

Conclusions

Genetic polymorphisms that influence pancreatic gland beta-cells insulin release and secretion associate with metabolic and anthropometric measures definitive for type 2 DM in Kazakh population.

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Authors and Affiliations

  1. Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Nur-Sultan, 80 Mangilik El Avenue / E495 bld. 2, Nur-Sultan, 010000, Republic of Kazakhstan

    Valeriy V. Benberin

  2. Gerontology Center, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Nur-Sultan, 80 Mangilik El Avenue / E495 bld. 2, Nur-Sultan, 010000, Republic of Kazakhstan

    Tamara A. Vochshenkova, Gulshara Zh. Abildinova, Anna V. Borovikova & Almagul A. Nagimtayeva

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  1. Valeriy V. Benberin
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Benberin, V.V., Vochshenkova, T.A., Abildinova, G.Z. et al. Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population. J Diabetes Metab Disord 20, 131–140 (2021). https://doi.org/10.1007/s40200-020-00720-z

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