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Nd:YAG photobiomodulation treatment in burning mouth syndrome: a pilot study

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Abstract

Objective

The aim of this study was to assess the effectiveness of Nd:YAG photobiomodulation (PBM) verse no power placebo with Nd:YAG in the treatment of patients with Burning mouth syndrome (BMS) in pain/burning, numbness, and altered taste.

Methods and materials

Forty-two patients with BMS were randomly equally assigned to PBM group and placebo group. The parameters of 1064-nm laser irradiation consisted of 100 mW power, 3 J/cm2, 30 s/region, and 10HZ. The placebo group used the same PBM instrument which was switched off. Each patient underwent one laser irradiation session per week for 4 weeks. Clinical assessments of subjective pain/burning, numbness, and altered taste were performed using a visual analogue score (VAS) before each irradiation session and 1 week after last treatment.

Results

All of the patients (21) in PBM group were showed significant decrease of VAS value of pain/burning (2% ~100%, mean 52%). The improvement on VAS value of numbness in PBM group (23% ~100%, mean 61%) was significant. Relief of altered taste was found neither in PBM group nor in placebo group. All patients completed this study and none of them reported adverse effects.

Conclusion

One thousand and sixty-four nanometers PBM was effective for reduction of pain/burning and numbness in patients with BMS.

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Data availability

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

BMS:

burning mouth syndrome

PBM:

photobiomodulation

RCT:

randomized controlled trial

VAS:

visual analogue scale

Sbaseline :

baseline session

S1:

1st session

S2:

2nd session

S3:

3rd session

S4:

4th session

Nd:YAG:

neodymium-doped yttrium aluminum garnet

IASP:

the International Association for the Study of Pain

gLMS:

generalized labeled magnitude scale

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Acknowledgements

The authors thank Dr Zhenyu Wu, Department of Biostatistics of Fudan University, for assistance in statistical analysis and thank the participating patients.

Funding

This work was supported by National Natural Science Foundation of China (No. 81671036).

Author information

Authors and Affiliations

  1. Department of Oral Mucosal Diseases, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao-Ju Road, Shanghai, 200011, China

    Chen Sun, Pan Xu, Qian-Qian Zhang & Wei-Wen Jiang

  2. National Clinical Research Center for Oral Diseases, Shanghai, China

    Chen Sun, Pan Xu, Qian-Qian Zhang & Wei-Wen Jiang

  3. Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, 639 Zhi-Zao-Ju Road, Shanghai, 200011, China

    Chen Sun, Pan Xu, Qian-Qian Zhang & Wei-Wen Jiang

Authors
  1. Chen Sun
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  2. Pan Xu
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  4. Wei-Wen Jiang
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Corresponding author

Correspondence to Wei-Wen Jiang.

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Ethics approval and consent to participate

The study was approved by Committee of Medical Ethics of Shanghai Ninth People’s Hospital (SH9H-2018-T18-2). Written informed consent was obtained from all patients.

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Not applicable.

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The authors declare no competing interests.

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Sun, C., Xu, P., Zhang, QQ. et al. Nd:YAG photobiomodulation treatment in burning mouth syndrome: a pilot study. Laser Dent Sci 5, 53–60 (2021). https://doi.org/10.1007/s41547-021-00116-z

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  • DOI: https://doi.org/10.1007/s41547-021-00116-z

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