Abstract
Key aspects of differences between liquid-phase parallel synthesis and preparation of a single compound at a time are reviewed. Specific technique and equipment is required to make in the parallel manner such processes as heating (involving MW ovens and flow microreactors), extraction, filtration, and chromatography. Rich illustrations may be useful in educational courses on medicinal and combinatorial chemistry.
Similar content being viewed by others
References
Babaev, E.V. and Ermolat’ev, D.S., Ross. Khim. Zh. (Zh. Ross. Khim. O-va im. D.I. Mendeleeva), 2009, vol. 53, no. 5, p. 42.
Babaev, E.V., Ibid., p. 57.
Antonenko, V., Combinatorial Chemistry and Technology. Principles, Methods and Applications, Miertus, S. and Fassina, G., Eds., New York: Marcel Dekker, 1999, p. 205.
Ivanova, N.V., Tkach, N.V., Belykh, E.N., Dlinnykh, I.V., and Babaev, E.V., Ross. Khim. Zh. (Zh. Ross. Khim. O-va im. D.I. Mendeleeva), 2009, vol. 53, no. 5, p. 105.
Mironov, M.A. and Babaev, E.V., Ibid., p. 133.
Ferrito, R., De Magistris, E., Vissio, A., Haio, A., and Seneci, P., Combinatorial Chemistry and Technology. Principles, Methods and Applications, Miertus, S. and Fassina, G., Eds., New York: Marcel Dekker, 1999, p. 53.
Kironi, P., Al’vares, M., and Al’berisio, F., Ross. Khim. Zh. (Zh. Ross. Khim. O-va im. D.I. Mendeleeva), 2009, vol. 53, no. 5, p. 73.
Kurran, D., Ibid., p. 87.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E. V. Babaev, 2009, published in Rossiiskii Khimicheskii Zhurnal, 2009, Vol. 53, No. 5, pp. 96–104.
Rights and permissions
About this article
Cite this article
Babaev, E.V. Little artifices of huge libraries: Secrets of parallel liquid-phase synthesis. Russ J Gen Chem 80, 2607–2616 (2010). https://doi.org/10.1134/S1070363210120273
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070363210120273